Rabbit MTDH Polyclonal Antibody | anti-MTDH antibody

MTDH Rabbit pAb

Cat. Num. AAA8545858

• Gene Names: MTDH; 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purified
• Synonyms: MTDH; Polyclonal Antibody; MTDH Rabbit pAb; 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3; anti-MTDH antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 582

• Applicable Applications for anti-MTDH antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MTDH (NP_848927.2).
• Cellular Localization: Cell Junction, Cytoplasm, Endoplasmic Reticulum, Membrane, Nucleus, Tight Junction
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-MTDH antibody

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

NCBI and Uniprot Product Information

• NCBI GI #: 223555917
• NCBI GeneID: 92140
• NCBI Accession #: NP_848927.2
• NCBI GenBank Nucleotide #: NP_848927.2
• UniProt Accession #: Q86UE4
• Molecular Weight: 64kDa
• NCBI Official Full Name: protein LYRIC isoform 1
• NCBI Official Synonym Full Names: metadherin
• NCBI Official Symbol: MTDH
• NCBI Official Synonym Symbols: 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
• NCBI Protein Information: protein LYRIC
• UniProt Protein Name: Protein LYRIC
• Protein Family: Protein LYRIC
• UniProt Gene Name: MTDH
• UniProt Synonym Gene Names: AEG1; LYRIC; AEG-1
• UniProt Entry Name: LYRIC_HUMAN

Uniprot Description

Lyric: a protein of unknown function.

Protein type: Cell adhesion; Nucleolus; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: apical plasma membrane; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; intercellular canaliculus; nuclear body; nuclear membrane; nucleolus; nucleus; perinuclear region of cytoplasm; tight junction

Molecular Function: double-stranded RNA binding; NF-kappaB binding; protein binding; transcription coactivator activity

Biological Process: activation of NF-kappaB transcription factor; lipopolysaccharide-mediated signaling pathway; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein kinase B signaling cascade