Rabbit MTA2 Polyclonal Antibody | anti-MTA2 antibody

MTA2 (Metastasis Associated Protein 2, DKFZp686F2281, Metastasis Associated 1 Family Member 2, Metastasis Associated 1-like 1, MTA1-L1 Protein, MTA1L1, Metastasis Associated Gene 1-like 1, Metastasis Associated Gene Family Member 2, Metastasis Associated

Cat. Num. AAA619298

• Gene Names: MTA2; PID; MTA1L1; DKFZp686F2281
• Reactivity: Human, Monkey
• Applications: Western Blot
• Purity: Affinity Purified; Purified by peptide immunoaffinity chromatography.
• Synonyms: MTA2; Polyclonal Antibody; MTA2 (Metastasis Associated Protein 2; DKFZp686F2281; Metastasis Associated 1 Family Member 2; Metastasis Associated 1-like 1; MTA1-L1 Protein; MTA1L1; Metastasis Associated Gene 1-like 1; Metastasis Associated Gene Family Member 2; Metastasis Associated; Anti -MTA2 (Metastasis Associated Protein 2; anti-MTA2 antibody

• Host: Rabbit
• Reactivity: Human, Monkey
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MTA2. Species Crossreactivity: Chimpanzee, Rhesus Monkey
• Purity/Purification: Affinity Purified; Purified by peptide immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

• Applicable Applications for anti-MTA2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-MTA2 antibody

Principal Names: Metastasis associated 1 family, member 2 (MTA2); MTA1-L1 protein; p53 target protein in deacetylase complex; PID; Official Gene Symbol: MTA2 Gen Bank Accession Number: NP_004730 Gene ID: 9219 (Human) Gene Map Locus: 11q12-q13.1 (human) MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family. It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependent transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of Estrogen receptor-alpha. Northern Blot analysis detected a ubiquitous expression of MTA2.

Product Categories/Family for anti-MTA2 antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 14141170
• NCBI GeneID: 9219
• NCBI Accession #: NP_004730.2
• NCBI GenBank Nucleotide #: NM_004739.3
• UniProt Accession #: O94776; Q9UQB5; Q68DB1
• Molecular Weight: 75,023 Da
• NCBI Official Full Name: metastasis-associated protein MTA2
• NCBI Official Synonym Full Names: metastasis associated 1 family, member 2
• NCBI Official Symbol: MTA2
• NCBI Official Synonym Symbols: PID; MTA1L1; DKFZp686F2281
• NCBI Protein Information: metastasis-associated protein MTA2; MTA1-L1 protein; OTTHUMP00000236453; OTTHUMP00000236454; OTTHUMP00000236455; metastasis-associated 1-like 1; metastasis-associated protein 2; metastasis -associated gene 1-like 1; p53 target protein in deacetylase complex; metastasis associated gene family, member 2
• UniProt Protein Name: Metastasis-associated protein MTA2
• Protein Family: Metastasis-associated protein
• UniProt Gene Name: MTA2
• UniProt Synonym Gene Names: MTA1L1; PID
• UniProt Entry Name: MTA2_HUMAN

NCBI Description

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq]

Uniprot Description

MTA2: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Protein type: Deacetylase; Motility/polarity/chemotaxis; DNA-binding; Transcription factor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11q12-q13.1

Cellular Component: nucleoplasm; transcription factor complex; protein complex; membrane; histone deacetylase complex; nuclear chromatin; NuRD complex

Molecular Function: protein binding; nucleosomal DNA binding; zinc ion binding; histone deacetylase activity; transcription factor activity

Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; DNA methylation; ATP-dependent chromatin remodeling; positive regulation of transcription from RNA polymerase II promoter; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter