Western Blot (WB)
(MTA2 pAb tested by Western blot. Nuclear extract (25 ug) of HEK293 (Lane 1) and CSML0 cells (Lane 2) was probed with MTA2 pAb (1:2,000).)
Rabbit MTA2 Polyclonal Antibody | anti-MTA2 antibody
MTA2 antibody (pAb)
Gene Names
MTA2; PID; MTA1L1
Reactivity
Human, Mouse, Wide Range Predicted
Applications
Western Blot
Synonyms
MTA2; Polyclonal Antibody; MTA2 antibody (pAb); PID; MTA1L1; anti-MTA2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Wide Range Predicted
Clonality
Polyclonal
Form/Format
Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Applicable Applications for anti-MTA2 antibody
Western Blot (WB)
Application Notes
Applications Validated:
WB: 1:500-1:2,000 dilution
WB: 1:500-1:2,000 dilution
Immunogen
This MTA2 antibody was raised against a peptide corresponding to the C-terminus of human MTA2.
Preparation and Storage
Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20 degree C for up to 2 years. Keep all reagents on ice when not in storage.1ug/ul
Western Blot (WB)
(MTA2 pAb tested by Western blot. Nuclear extract (25 ug) of HEK293 (Lane 1) and CSML0 cells (Lane 2) was probed with MTA2 pAb (1:2,000).)
Western Blot (WB)
(MTA2 pAb tested by Western blot. Nuclear extract (25 ug) of HEK293 (Lane 1) and CSML0 cells (Lane 2) was probed with MTA2 pAb (1:2,000).)
Related Product Information for anti-MTA2 antibody
Short Description: Our MTA2 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot; it has been shown to react with Human and Mouse samples, but it is predicted that it will react with a wide range of sample types.
Background: MTA2 (Metastasis-associated protein 2) is a member of the Mi-2/NuRD complex, a nucleosome (chromatin) remodeling deacetylase complex. The MTA family sequences contain several common domains, potentially involved in protein-protein interactions (BAH domain), in DNA binding (SANT domain and GATA-type zinc finger motif) and in signal transduction involving many kinase, adaptor and scaffolding proteins (src-homology (SH)-binding motifs). Tumor suppressor p53 protein is deacetylated by both MTA1 and MTA2, leading to inhibition of growth arrest in transforming cells supporting a link between these protein family members and metastasis. MTA2 is ubiquitously expressed.
Background: MTA2 (Metastasis-associated protein 2) is a member of the Mi-2/NuRD complex, a nucleosome (chromatin) remodeling deacetylase complex. The MTA family sequences contain several common domains, potentially involved in protein-protein interactions (BAH domain), in DNA binding (SANT domain and GATA-type zinc finger motif) and in signal transduction involving many kinase, adaptor and scaffolding proteins (src-homology (SH)-binding motifs). Tumor suppressor p53 protein is deacetylated by both MTA1 and MTA2, leading to inhibition of growth arrest in transforming cells supporting a link between these protein family members and metastasis. MTA2 is ubiquitously expressed.
Product Categories/Family for anti-MTA2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,037 Da
NCBI Official Full Name
metastasis-associated protein MTA2
NCBI Official Synonym Full Names
metastasis associated 1 family, member 2
NCBI Official Symbol
MTA2
NCBI Official Synonym Symbols
PID; MTA1L1
NCBI Protein Information
metastasis-associated protein MTA2; MTA1-L1 protein; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated protein 2; p53 target protein in deacetylase complex
UniProt Protein Name
Metastasis-associated protein MTA2
Protein Family
UniProt Gene Name
MTA2
UniProt Synonym Gene Names
MTA1L1; PID; MTA1-L1 protein
UniProt Entry Name
MTA2_HUMAN
Uniprot Description
MTA2: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Protein type: Transcription factor; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Deacetylase
Chromosomal Location of Human Ortholog: 11q12-q13.1
Cellular Component: nucleoplasm; transcription factor complex; protein complex; membrane; histone deacetylase complex; nuclear chromatin; NuRD complex
Molecular Function: protein binding; nucleosomal DNA binding; zinc ion binding; histone deacetylase activity; transcription factor activity
Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; ATP-dependent chromatin remodeling; DNA methylation; positive regulation of transcription from RNA polymerase II promoter; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter
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Product Notes
The MTA2 mta2 (Catalog #AAA388455) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MTA2 antibody (pAb) reacts with Human, Mouse, Wide Range Predicted and may cross-react with other species as described in the data sheet. AAA Biotech's MTA2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications Validated: WB: 1:500-1:2,000 dilution. Researchers should empirically determine the suitability of the MTA2 mta2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MTA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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