Rabbit anti-Human Msx2 Polyclonal Antibody | anti-MSX2 antibody

Msx2, CT (Homeobox protein MSX-2, Hox-8, MSX2, HOX8)

Cat. Num. AAA6005335

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Msx2; Polyclonal Antibody; CT (Homeobox protein MSX-2; Hox-8; MSX2; HOX8); Anti -Msx2; anti-MSX2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-MSX2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:50-100; Immunohistochemistry: 1:10-50
• Immunogen: Msx2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MSX2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of Msx2 (arrow) using rabbit polyclonal Msx2 Antibody (Human C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Msx2 gene (Lane 2) (Origene Technologies).)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Msx2 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Related Product Information for anti-MSX2 antibody

This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.

Product Categories/Family for anti-MSX2 antibody

Antibodies; Abs to Transcription Factors; Zinc; Ring; Homeobox

NCBI and Uniprot Product Information

• NCBI GI #: 124111252
• NCBI GeneID: 744194
• UniProt Accession #: A2T764
• Molecular Weight: 28,921 Da
• NCBI Official Full Name: MSX2
• NCBI Official Symbol: MSX2
• NCBI Protein Information: homeobox protein MSX-2
• UniProt Protein Name: Homeobox protein MSX-2
• Protein Family: Msx2-interacting protein
• UniProt Gene Name: MSX2
• UniProt Entry Name: MSX2_PANTR

Uniprot Description

Function: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter

By similarity.

Subcellular location: Nucleus

By similarity.

Sequence similarities: Belongs to the Msh homeobox family.Contains 1 homeobox DNA-binding domain.