Goat MSX1 Polyclonal Antibody | anti-MSX1 antibody

Goat Polyclonal to Human MSX1

Cat. Num. AAA242013

• Gene Names: MSX1; HOX7; HYD1; ECTD3; STHAG1
• Reactivity: Gibbon, Bovine, Chimpanzee, Human, Monkey, Mouse, Orangutan, Pig, Rat; Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: MSX1; Polyclonal Antibody; Goat Polyclonal to Human MSX1; Anti-MSX1 Antibody (N-Terminus) IHC-plus; ECTD3; Homeobox protein MSX-1; HOX7; Msh homeo box 1; Homeobox 7; OFC5; STHAG1; Msh homeobox homolog 1; Homeobox protein Hox-7; HYD1; Msh homeobox 1; Msh homeobox 1-like protein; Human MSX1; anti-MSX1 antibody

• Host: Goat
• Reactivity: Gibbon, Bovine, Chimpanzee, Human, Monkey, Mouse, Orangutan, Pig, Rat; Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human MSX1.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 303

• Applicable Applications for anti-MSX1 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:16000), IHC-P (2.5 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide TSLPLGVKVEDS-C from the N-terminus of human MSX1 (NP_002439.2). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Tamarin, Mouse, Rat, Elephant, Bovine, Pig (100%); Gorilla (92%).
• Immunogen Type: Synthetic peptide
• Immunogen: MSX1 antibody was raised against synthetic peptide TSLPLGVKVEDS-C from the N-terminus of human MSX1 (NP_002439.2). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Tamarin, Mouse, Rat, Elephant, Bovine, Pig (100%); Gorilla (92%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-MSX1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 118582284
• NCBI GeneID: 4487
• NCBI Accession #: NP_002439.2
• NCBI GenBank Nucleotide #: NM_002448.3
• UniProt Accession #: P28360; Q96NY4; A0SZU5; A8K3M1
• Molecular Weight: 31,496 Da
• NCBI Official Full Name: homeobox protein MSX-1
• NCBI Official Synonym Full Names: msh homeobox 1
• NCBI Official Symbol: MSX1
• NCBI Official Synonym Symbols: HOX7; HYD1; ECTD3; STHAG1
• NCBI Protein Information: homeobox protein MSX-1; homeobox 7; msh homeo box 1; homeobox protein Hox-7; msh homeobox homolog 1; msh homeobox 1-like protein
• UniProt Protein Name: Homeobox protein MSX-1
• Protein Family: Homeobox protein
• UniProt Gene Name: MSX1
• UniProt Synonym Gene Names: HOX7
• UniProt Entry Name: MSX1_HUMAN

NCBI Description

This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]

Uniprot Description

MSX1: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family.

Protein type: Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 4p16.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: p53 binding

Biological Process: embryonic forelimb morphogenesis; negative regulation of striated muscle cell differentiation; transcription from RNA polymerase II promoter; muscle development; protein stabilization; in utero embryonic development; regulation of odontogenesis; mesenchymal cell proliferation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; palate development; middle ear morphogenesis; embryonic hindlimb morphogenesis; odontogenesis of dentine-containing teeth; anterior/posterior pattern formation; negative regulation of cell proliferation; pituitary gland development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell growth; positive regulation of BMP signaling pathway; negative regulation of apoptosis

Disease: Orofacial Cleft 5; Witkop Syndrome; Tooth Agenesis, Selective, 1