Rabbit anti-Human MSI2 Polyclonal Antibody | anti-MSI2 antibody

MSI2 (RNA-binding Protein Musashi Homolog 2, Musashi-2, FLJ36569, MGC3245, Musashi-2) (FITC)

Cat. Num. AAA6385987

• Gene Names: MSI2; MSI2H
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MSI2; Polyclonal Antibody; MSI2 (RNA-binding Protein Musashi Homolog 2; Musashi-2; FLJ36569; MGC3245; Musashi-2) (FITC); anti-MSI2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MSI2.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-MSI2 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human MSI2, aa1-328 (NP_620412.1).
• Immunogen Sequence: MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(MSI2 rabbit polyclonal antibody. Western Blot analysis of MSI2 expression in human liver.)

Western Blot (WB)

(Western Blot analysis of MSI2 expression in transfected 293T cell line by MSI2 polyclonal antibody. Lane 1: MSI2 transfected lysate (35.2kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-MSI2 antibody

RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.

Product Categories/Family for anti-MSI2 antibody

Antibodies; RNA Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 20373175
• NCBI GeneID: 124540
• NCBI Accession #: NP_620412.1
• NCBI GenBank Nucleotide #: NM_138962.2
• UniProt Accession #: Q96DH6; Q7Z6M7; Q8N9T4
• Molecular Weight: 17,238 Da
• NCBI Official Full Name: RNA-binding protein Musashi homolog 2 isoform a
• NCBI Official Synonym Full Names: musashi RNA-binding protein 2
• NCBI Official Symbol: MSI2
• NCBI Official Synonym Symbols: MSI2H
• NCBI Protein Information: RNA-binding protein Musashi homolog 2; musashi homolog 2; musashi-2
• UniProt Protein Name: RNA-binding protein Musashi homolog 2
• Protein Family: RNA-binding protein
• UniProt Gene Name: MSI2
• UniProt Synonym Gene Names: Musashi-2
• UniProt Entry Name: MSI2H_HUMAN

NCBI Description

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Musashi-2: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23). Belongs to the Musashi family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: polysome; cytoplasm

Molecular Function: nucleotide binding; poly(U) binding

Biological Process: stem cell development