Rabbit MRP1 Polyclonal Antibody | anti-ABCC1 antibody

Anti-MRP1 antibody

Cat. Num. AAA175406

• Gene Names: ABCC1; MRP; ABCC; GS-X; MRP1; ABC29
• Reactivity: Human, Mouse, Rat. No cross reactivity with other proteins.
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified.
• Synonyms: MRP1; Polyclonal Antibody; Anti-MRP1 antibody; Multidrug resistance-associated protein 1; ATP-binding cassette; sub-family C(CFTR/MRP); member 1; ABC 29 antibody; ABC29 antibody; ABCC 1 antibody; ABCC antibody; ABCC1 antibody; ATP binding cassette sub family C(CFTR/MRP) member 1 antibody; ATP binding cassette sub-family C member 1 antibody; ATP-binding cassette sub-family C member 1 antibody; DKFZp686N04233 antibody; DKFZp781G125 antibody; GS X antibody; GSX antibody; Leukotriene C(4) transporter antibody; LTC4 transporter antibody; MRP 1 antibody; MRP antibody; MRP1_HUMAN antibody; Multidrug resistance associated protein 1 antibody; Multidrug resistance protein antibody; Multidrug resistance-associated protein 1 antibody; Multiple drug resistance associated protein antibody; Multiple drug resistance protein 1 antibody; anti-ABCC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat. No cross reactivity with other proteins.
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized; Contains 5mg BSA, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg Thimerosal, 0.05mg NaN₃.
• Sequence Length: 1531

• Applicable Applications for anti-ABCC1 antibody: Western Blot (WB), Immunohistochemistry (IHC) (Paraffin-embedded Section)
• Application Notes: Western blot:; Concentration: 0.1-0.5ug/ml; Tested Species: Human, Rat; Concluded Species: Mouse; Antigen Retrieval: -; ; Immunohistochemistry (Paraffin-embedded Section): ; Concentration: 0.5-1ug/ml/ml; Tested Species: Human ; Predicted Species: Mouse, Rat; Antigen Retrieval: By Heat; ; Other applications have not been tested.; Optimal dilutions should be determined by end users.
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1 (1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.
• Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-MRP1 antibody, MBS175406, Western blottingLane 1: JURKAT Cell LysateLane 2: CEM Cell LysateLane 3: A549 Cell Lysate )

Related Product Information for anti-ABCC1 antibody

ABCC1(ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1), also called MRP1 or MRP, is a protein that in humans is encoded by the ABCC1 gene. The ABCC1 is a member of the superfamily of ATP-binding cassette(ABC) transporters. The ABCC1 is a plasma membrane drug-efflux pump.The ABCC1 gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking ABCC1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that ABCC1 is an important protector in this scenario. ABCC1 clears beta-amyloid from brains of mice and can be activated by thiethylperazine. And Chemotaxis assays show that ABCC1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.

NCBI and Uniprot Product Information

• NCBI GI #: 296439301
• NCBI GeneID: 4363
• UniProt Accession #: P33527; O14819; O43333; P78419; Q59GI9; Q9UQ97; Q9UQ99; Q9UQA0; A3RJX2; C9JPJ4
• NCBI Official Full Name: Multidrug resistance-associated protein 1
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
• NCBI Official Symbol: ABCC1
• NCBI Official Synonym Symbols: MRP; ABCC; GS-X; MRP1; ABC29
• NCBI Protein Information: multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25&26
• UniProt Protein Name: Multidrug resistance-associated protein 1
• Protein Family: Multidrug resistance-associated protein
• UniProt Gene Name: ABCC1
• UniProt Synonym Gene Names: MRP; MRP1; LTC4 transporter
• UniProt Entry Name: MRP1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

Uniprot Description

ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATPase activity; ATP binding

Biological Process: response to drug; vitamin metabolic process; cobalamin metabolic process; transport; arachidonic acid metabolic process; leukotriene metabolic process; transmembrane transport; water-soluble vitamin metabolic process