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Rabbit anti-Human MRGPRX2 Polyclonal Antibody | anti-MRGPRX2 antibody

MRGPRX2 antibody

Gene Names
MRGPRX2; MGRG3; MRGX2
Reactivity
Human
Applications
Immunohistochemistry
Purity
MRGPRX2 antibody was purified by affinity chromatography.
Synonyms
MRGPRX2; Polyclonal Antibody; MRGPRX2 antibody; Polyclonal MRGPRX2; Anti-MRGPRX2; MRGPRX -2; MRGX3; MRGPRX 2; anti-MRGPRX2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human
Purity/Purification
MRGPRX2 antibody was purified by affinity chromatography.
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
330
Applicable Applications for anti-MRGPRX2 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes
IHC-P: 20 ug/ml
Biological Significance
G protein-coupled receptors (GPCRs), comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
MRGPRX2 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-MRGPRX2 antibody
Rabbit polyclonal MRGPRX2 antibody
Product Categories/Family for anti-MRGPRX2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37,099 Da
NCBI Official Full Name
mas-related G-protein coupled receptor member X2
NCBI Official Synonym Full Names
MAS-related GPR, member X2
NCBI Official Symbol
MRGPRX2
NCBI Official Synonym Symbols
MGRG3; MRGX2
NCBI Protein Information
mas-related G-protein coupled receptor member X2
UniProt Protein Name
Mas-related G-protein coupled receptor member X2
UniProt Gene Name
MRGPRX2
UniProt Synonym Gene Names
MRGX2
UniProt Entry Name
MRGX2_HUMAN

Uniprot Description

MRGPRX2: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; sleep; sensory perception of pain

Research Articles on MRGPRX2

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Product Notes

The MRGPRX2 mrgprx2 (Catalog #AAA535626) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MRGPRX2 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MRGPRX2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin. IHC-P: 20 ug/ml. Researchers should empirically determine the suitability of the MRGPRX2 mrgprx2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MRGPRX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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