Western Blot (WB)
(MRE11 pAb tested by Western blot. MRE11 detection by Western blot. The analysis was performed using 293 whole-cell extract and MRE11 pAb at a 2 ug/ml dilution.)
Rabbit anti-Human MRE11 Polyclonal Antibody | anti-MRE11 antibody
MRE11 antibody (pAb)
Gene Names
MRE11A; ATLD; HNGS1; MRE11; MRE11B
Reactivity
Human
Applications
Western Blot
Purity
Affinity Purified
Synonyms
MRE11; Polyclonal Antibody; MRE11 antibody (pAb); MRE11A; ATLD; HNGS1; MRE11B; anti-MRE11 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purified
Form/Format
PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Concentration
0.5ug/ul (varies by lot)
Applicable Applications for anti-MRE11 antibody
Western Blot (WB)
Application Notes
Applications Validated:
WB: 1-2ug/ml dilution
For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background.
WB: 1-2ug/ml dilution
For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background.
Immunogen
This MRE11 antibody was raised against a synthetic peptide corresponding to human MRE11.
Preparation and Storage
Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20 degree C for up to 2 years. Keep all reagents on ice when not in storage.1ug/ul
Western Blot (WB)
(MRE11 pAb tested by Western blot. MRE11 detection by Western blot. The analysis was performed using 293 whole-cell extract and MRE11 pAb at a 2 ug/ml dilution.)
Western Blot (WB)
(MRE11 pAb tested by Western blot. MRE11 detection by Western blot. The analysis was performed using 293 whole-cell extract and MRE11 pAb at a 2 ug/ml dilution.)
Related Product Information for anti-MRE11 antibody
Short Description: Our MRE11 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot; it has been shown to react with Human samples.
Background: MRE11 (ATLD or HNGS1) is a component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (ATLD or HNGS1). Rad50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 (ATLD or HNGS1) to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres, the MRN complex may modulate t-loop formation.
Background: MRE11 (ATLD or HNGS1) is a component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (ATLD or HNGS1). Rad50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 (ATLD or HNGS1) to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres, the MRN complex may modulate t-loop formation.
Product Categories/Family for anti-MRE11 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
59,724 Da
NCBI Official Full Name
double-strand break repair protein MRE11A isoform 2
NCBI Official Synonym Full Names
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NCBI Official Symbol
MRE11A
NCBI Official Synonym Symbols
ATLD; HNGS1; MRE11; MRE11B
NCBI Protein Information
double-strand break repair protein MRE11A; AT-like disease; DNA recombination and repair protein; MRE11 homolog 1; MRE11 homolog A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A
UniProt Protein Name
MRE11A protein
Protein Family
UniProt Gene Name
MRE11A
UniProt Entry Name
Q05D78_HUMAN
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Product Notes
The MRE11 mre11a (Catalog #AAA388416) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MRE11 antibody (pAb) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MRE11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications Validated: WB: 1-2ug/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background. Researchers should empirically determine the suitability of the MRE11 mre11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MRE11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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