Western Blot (WB)
(MRC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MRC2 antibody detected the MRC2 protein (arrow).)
Rabbit anti-Human MRC2 Polyclonal Antibody | anti-MRC2 antibody
MRC2 Antibody (Center)
Western Blot (WB)
(MRC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MRC2 antibody detected the MRC2 protein (arrow).)
Western Blot (WB)
(MRC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MRC2 antibody detected the MRC2 protein (arrow).)
cell motility and remodeling of the extracellular matrix by
promoting cell migration and uptake of collagens for intracellular
degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by
OMIM].
Wu, X., et al. Cancer Prev Res (Phila Pa) 2(7):617-624(2009)
Wienke, D., et al. Cancer Res. 67(21):10230-10240(2007)
Sulek, J., et al. J. Histochem. Cytochem. 55(4):347-353(2007)
Johnson, J.M., et al. Science 302(5653):2141-2144(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Uniprot Description
MRC2: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: focal adhesion; membrane; integral to membrane
Molecular Function: collagen binding; protein binding; carbohydrate binding
Biological Process: osteoblast differentiation; collagen catabolic process; endocytosis
Research Articles on MRC2
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Product Notes
The MRC2 mrc2 (Catalog #AAA9213880) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 798-827. The MRC2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MRC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MRC2 mrc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MRC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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