Rabbit anti-Human, Mouse MPP6 Polyclonal Antibody | anti-MPHOSPH6 antibody

MPP6, ID (MPP6, VAM1, MAGUK p55 subfamily member 6, Veli-associated MAGUK 1)

Cat. Num. AAA6008169

• Gene Names: MPHOSPH6; MPP; MPP6; MPP-6
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Flow Cytometry, Functional Assay
• Purity: Purified; Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Synonyms: MPP6; Polyclonal Antibody; ID (MPP6; VAM1; MAGUK p55 subfamily member 6; Veli-associated MAGUK 1); Anti -MPP6; anti-MPHOSPH6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, mouse
• Purity/Purification: Purified; Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-MPHOSPH6 antibody: ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Western Blot, Flow Cytometry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:50-100; Flow Cytometry: 1:10-50
• Immunogen: MPP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367~396 amino acids from the Center region of human MPP6.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of MPP6 Antibody (Center) in mouse cerebellum tissue lysates (35ug/lane). MPP6 (arrow) was detected using the purified Pab.)

Flow Cytometry (FC/FACS)

(MPP6 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-MPHOSPH6 antibody

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily.

Product Categories/Family for anti-MPHOSPH6 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 118498352
• NCBI GeneID: 10200
• NCBI Accession #: NP_005783.2
• NCBI GenBank Nucleotide #: NM_005792.2
• UniProt Accession #: Q99547; B2RAF0
• Molecular Weight: 19,024 Da
• NCBI Official Full Name: M-phase phosphoprotein 6
• NCBI Official Synonym Full Names: M-phase phosphoprotein 6
• NCBI Official Symbol: MPHOSPH6
• NCBI Official Synonym Symbols: MPP; MPP6; MPP-6
• NCBI Protein Information: M-phase phosphoprotein 6
• UniProt Protein Name: M-phase phosphoprotein 6
• Protein Family: M-phase phosphoprotein
• UniProt Gene Name: MPHOSPH6
• UniProt Synonym Gene Names: MPP6
• UniProt Entry Name: MPH6_HUMAN

Uniprot Description

MPHOSPH6: RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Belongs to the MPP6 family.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16q23.3

Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); nucleus; nuclear exosome (RNase complex)

Molecular Function: protein binding; RNA binding

Biological Process: maturation of 5.8S rRNA