Rabbit anti-Human, Mouse MPP1 Polyclonal Antibody | anti-MPP1 antibody

MPP1 Polyclonal Antibody

Cat. Num. AAA3011490

• Gene Names: MPP1; MRG1; PEMP; AAG12; EMP55; DXS552E
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: MPP1; Polyclonal Antibody; MPP1 Polyclonal Antibody; 55 kDa erythrocyte membrane protein; p55; Membrane protein; palmitoylated 1; DXS552E; EMP55; anti-MPP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MPP1 polyclonal antibody detects endogenous levels of MPP1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 449

• Applicable Applications for anti-MPP1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant full length Human MPP1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of MPP1 polyclonal antibody)

Related Product Information for anti-MPP1 antibody

The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. MPP1 (M-phase phosphoprotein 1), also known as KIF20B (kinesin family member 20B), MPHOSPH1 or KRMP1, is a 1, 820 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one kinesin-motor domain. Expressed in kidney, brain, testis and ovary, MPP1 functions as a plus-end directed motor enzyme that interacts with Pin1 and is required for the completion of cytokinesis. MPP1, which exists as multiple alternatively spliced isoforms termed 1-5, is subject to post-translational phosphorylation, probably by ATM or ATR.

NCBI and Uniprot Product Information

• NCBI GI #: 262118255
• NCBI GeneID: 4354
• NCBI Accession #: NP_001159932.1
• NCBI GenBank Nucleotide #: NP_001159932.1
• UniProt Accession #: Q00013
• Molecular Weight: ~ 52kDa
• NCBI Official Full Name: 55 kDa erythrocyte membrane protein isoform 2
• NCBI Official Synonym Full Names: membrane palmitoylated protein 1
• NCBI Official Symbol: MPP1
• NCBI Official Synonym Symbols: MRG1; PEMP; AAG12; EMP55; DXS552E
• NCBI Protein Information: 55 kDa erythrocyte membrane protein
• UniProt Protein Name: 55 kDa erythrocyte membrane protein
• Protein Family: Mitochondrial-processing peptidase
• UniProt Gene Name: MPP1
• UniProt Synonym Gene Names: DXS552E; EMP55; p55
• UniProt Entry Name: EM55_HUMAN

NCBI Description

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]