Rabbit MOX1 Polyclonal Antibody | anti-MEOX1 antibody

MOX1 Antibody

Cat. Num. AAA150345

• Gene Names: MEOX1; KFS2; MOX1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunocytochemistry, Immunofluorescence
• Purity: MOX1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: MOX1; Polyclonal Antibody; MOX1 Antibody; KFS2; Homeobox protein MOX-1; Mesenchyme homeobox 1; mesenchyme homeobox 1; anti-MEOX1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: MOX1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 254

• Applicable Applications for anti-MEOX1 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: MOX1 antibody can be used for detection of MOX1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: MOX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human MOX1.
• Buffer: MOX1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: MOX1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of MOX1 in human liver tissue lysate with MOX1 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of MOX1 in rat liver tissue with MOX1 antibody at 10 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of MOX1 in rat liver tissue with MOX1 antibody at 20 μg/mL.)

Related Product Information for anti-MEOX1 antibody

MOX1 Antibody: MOX1, also known as MEOX1, is a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes that is first expressed during gastrulation in the early mesoderm and later in presomitic mesoderm, early somites, dermomyotome and sclerotome. Both MOX1 and the related protein MOX2 are required for proper gene expression in all somitic compartments. MOX1 is an upstream regulator of the transcription factors Bapx1, Tbx18, and Uncx and is thus part of a regulatory circuit that functions in the maintenance of rostrocaudal sclerotome polarity and axial skeleton formation.

NCBI and Uniprot Product Information

• NCBI GI #: 4758710
• NCBI GeneID: 4222
• NCBI Accession #: NP_004518
• NCBI GenBank Nucleotide #: NM_004527.3
• UniProt Accession #: P50221; Q15069; A8K524; A8MWF9
• Molecular Weight: 15,628 Da
• NCBI Official Full Name: homeobox protein MOX-1 isoform 1
• NCBI Official Synonym Full Names: mesenchyme homeobox 1
• NCBI Official Symbol: MEOX1
• NCBI Official Synonym Symbols: KFS2; MOX1
• NCBI Protein Information: homeobox protein MOX-1
• UniProt Protein Name: Homeobox protein MOX-1
• Protein Family: Homeobox protein
• UniProt Gene Name: MEOX1
• UniProt Synonym Gene Names: MOX1
• UniProt Entry Name: MEOX1_HUMAN

NCBI Description

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

MEOX1: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: somite specification; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter

Disease: Klippel-feil Syndrome 2, Autosomal Recessive