Rabbit anti-Human MORF4L2 Polyclonal Antibody | anti-MORF4L2 antibody

MORF4L2, CT (MORF4L2, KIAA0026, MRGX, Mortality factor 4-like protein 2, MORF-related gene X protein, Protein MSL3-2, Transcription factor-like protein MRGX) (Biotin)

Cat. Num. AAA6321704

• Gene Names: MORF4L2; MRGX; MORFL2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MORF4L2; Polyclonal Antibody; CT (MORF4L2; KIAA0026; MRGX; Mortality factor 4-like protein 2; MORF-related gene X protein; Protein MSL3-2; Transcription factor-like protein MRGX) (Biotin); Transcription factor-like protein MRGX; anti-MORF4L2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 288

• Applicable Applications for anti-MORF4L2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: MORF4L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-288 amino acids from the C-terminal region of human MORF4L2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(MORF4L2 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MORF4L2 antibody detected the MORF4L2 protein (arrow).)

Related Product Information for anti-MORF4L2 antibody

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Product Categories/Family for anti-MORF4L2 antibody

Antibodies; Transcription Factors

References

Pezo, R.C., et al. Cancer Res. 68(13):4977-4982(2008). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005). Cai, Y., et al. J. Biol. Chem. 280(14):13665-13670(2005). Tominaga, K., et al. J. Biol. Chem. 278(49):49618-49624(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 215490043
• NCBI GeneID: 9643
• NCBI Accession #: NP_001135901.1; NP_001135891.1; NP_001135898.1
• NCBI GenBank Nucleotide #: NP_001135901.1
• UniProt Accession #: Q15014
• NCBI Official Full Name: mortality factor 4-like protein 2
• NCBI Official Synonym Full Names: mortality factor 4 like 2
• NCBI Official Symbol: MORF4L2
• NCBI Official Synonym Symbols: MRGX; MORFL2
• NCBI Protein Information: mortality factor 4-like protein 2
• UniProt Protein Name: Mortality factor 4-like protein 2
• Protein Family: Mortality factor 4-like protein
• UniProt Gene Name: MORF4L2
• UniProt Synonym Gene Names: KIAA0026; MRGX
• UniProt Entry Name: MO4L2_HUMAN

Uniprot Description

MORF4L2: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: nucleoplasm; nucleolus

Molecular Function: protein binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of striated muscle cell differentiation; chromatin modification; DNA repair