Goat MORF4L1 / MRG15 Polyclonal Antibody | anti-MORF4L1 antibody

Goat Polyclonal to Human MORF4L1 / MRG15

Cat. Num. AAA242484

• Gene Names: MORF4L1; Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15
• Reactivity: Gibbon, Bovine, Gorilla, Human, Monkey, Mouse, Orangutan, Pig, Rat, Zebrafish; Predicted Reactivity: Hamster, Rabbit, Xenopus (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: MORF4L1 / MRG15; Polyclonal Antibody; Goat Polyclonal to Human MORF4L1 / MRG15; Anti-MORF4L1 / MRG15 Antibody (N-Terminus) IHC-plus; MORF4L1; Eaf3; Mortality factor 4 like 1; HsT17725; Protein MSL3-1; MEAF3; MORFRG15; MRG15; FWP006; MORF-related gene 15 protein; S863-6; Human MORF4L1; anti-MORF4L1 antibody

• Host: Goat
• Reactivity: Gibbon, Bovine, Gorilla, Human, Monkey, Mouse, Orangutan, Pig, Rat, Zebrafish; Predicted Reactivity: Hamster, Rabbit, Xenopus (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human MORF4L1 / MRG15.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 323

• Applicable Applications for anti-MORF4L1 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:64000), IHC-P (2.5 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide (APKQDPKPKFQEG-C) from N-terminus of human MORF4L1.
• Immunogen Type: Synthetic peptide
• Immunogen: MORF4L1 / MRG15 antibody was raised against synthetic peptide (APKQDPKPKFQEG-C) from N-terminus of human MORF4L1. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Bovine, Pig, Opossum, Trout, Salmon, Smelt, Sablefish, Stickleback, Pufferfish, Zebrafish (100%); Hamster, Rabbit, Xenopus (92%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-MORF4L1 / MRG15 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-MORF4L1 / MRG15 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 5803102
• NCBI GeneID: 10933
• NCBI Accession #: NP_006782.1
• NCBI GenBank Nucleotide #: NM_006791.3
• UniProt Accession #: Q9UBU8; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; B4DKN6; B7Z6R1; D3DW88
• Molecular Weight: 26,750 Da
• NCBI Official Full Name: mortality factor 4-like protein 1 isoform 1
• NCBI Official Synonym Full Names: mortality factor 4 like 1
• NCBI Official Symbol: MORF4L1
• NCBI Official Synonym Symbols: Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15
• NCBI Protein Information: mortality factor 4-like protein 1; protein MSL3-1; MORF-related gene 15 protein; Esa1p-associated factor 3 homolog; MORF-related gene on chromosome 15; transcription factor-like protein MRG15
• UniProt Protein Name: Mortality factor 4-like protein 1
• Protein Family: Mortality factor 4-like protein
• UniProt Gene Name: MORF4L1
• UniProt Synonym Gene Names: MRG15
• UniProt Entry Name: MO4L1_HUMAN

Uniprot Description

MORF4L1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; Sin3 complex

Molecular Function: protein binding; protein N-terminus binding; chromatin binding

Biological Process: cell proliferation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of growth; histone deacetylation; double-strand break repair via homologous recombination