Rabbit anti-Human Monocarboxylate Transporter 2 Polyclonal Antibody | anti-SLC16A7 antibody

Monocarboxylate Transporter 2 (MCT2, MOT2)

Cat. Num. AAA614742

• Gene Names: SLC16A7; MCT2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Monocarboxylate Transporter 2; Polyclonal Antibody; Monocarboxylate Transporter 2 (MCT2; MOT2); Anti -Monocarboxylate Transporter 2 (MCT2; anti-SLC16A7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Monocarboxylate Transporter 2 (MCT2). The immunogen shows no significant sequence homology with other MCT.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% BSA.

• Applicable Applications for anti-SLC16A7 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot and ELISA.; Dilution: Western Blot: 1-5ug/ml using ECL.; ELISA: 1:10,000-1:100,000 Using 50-100ng M4470-12A control peptide/well.
• Immunogen: A synthetic peptide corresponding to 15aa near the C-terminal, cytoplasmic domain of human MCT2, conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SLC16A7 antibody

Monocarboxylate such as lactate and pyruvate play an important role in cellular metabolism. Lactic acid is produced as the end product of glycolysis. Some tissues, such as white skeletal muscle and, red blood cells, use this pathway to generate most of their ATP under normal physiological conditions. All tissues become dependent on this pathway during abnormal conditions such as hypoxia and ischaemia. Lactic acid, produced during normal glycolysis, must be transported out of cells to sustain maintain high rate of glycolysis. Failure to export lactic acid leads to accumulation of cellular lactic acid followed by an increase in pH and inhibition of glycolysis. Some tissues, such as brain, heart, and red skeletal muscle, readily oxidize lactic acid, and must import lactic acid into the cells. Lactic acid transport is mediated by a group of proton-linked membrane transporters called monocarboxylic acid transporters (MCTs). At least 9 MCT-related proteins (MCT1-9) have been identified in mammals that are expressed in a tissue specific manner.

Product Categories/Family for anti-SLC16A7 antibody

Antibodies; Abs to Monocarboxylate Transporter

NCBI and Uniprot Product Information

• NCBI GI #: 24431958
• NCBI GeneID: 9194
• NCBI Accession #: NP_004722.2
• NCBI GenBank Nucleotide #: NM_004731.3
• UniProt Accession #: O60669; Q9UPB3; Q8NEM3
• Molecular Weight: 52,200 Da
• NCBI Official Full Name: monocarboxylate transporter 2
• NCBI Official Synonym Full Names: solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
• NCBI Official Symbol: SLC16A7
• NCBI Official Synonym Symbols: MCT2
• NCBI Protein Information: monocarboxylate transporter 2; MCT 2; solute carrier family 16 member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7
• UniProt Protein Name: Monocarboxylate transporter 2
• Protein Family: Monocarboxylate transporter
• UniProt Gene Name: SLC16A7
• UniProt Synonym Gene Names: MCT2
• UniProt Entry Name: MOT2_HUMAN

NCBI Description

Tissues with few or no mitochondria, such as erythrocytes and tumor cells, depend largely on glycolysis to generate ATP. The major end products of glycolysis, pyruvate and lactate, must be eliminated from these cells to enable continued glycolytic flux and prevent toxic effects. H+/monocarboxylate transporters (MCTs) mediate the transport of lactate and pyruvate. Human MCT2 has a high affinity for the transport of pyruvate (summary by Lin et al., 1998 [PubMed 9786900]).[supplied by OMIM]

Uniprot Description

SLC16A7: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: pyruvate secondary active transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; pyruvate transmembrane transporter activity

Biological Process: transmembrane transport