Rabbit anti-Human MOG Polyclonal Antibody | anti-MOG antibody

MOG, ID (MOG, Myelin-oligodendrocyte glycoprotein) (MaxLight 750)

Cat. Num. AAA6321645

• Gene Names: MOG; BTN6; BTNL11; MOGIG2; NRCLP7
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: MOG; Polyclonal Antibody; ID (MOG; Myelin-oligodendrocyte glycoprotein) (MaxLight 750); Myelin-oligodendrocyte glycoprotein; anti-MOG antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MOG.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-MOG antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 82-109 in the central region of human MOG, UniProt Accession #Q16653. Species sequence homology: monkey
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in K562 cell line lysates (35ug/lane) usingMBS6007210. This demonstrates that MBS6007210 detected the MOG protein (arrow).)

Related Product Information for anti-MOG antibody

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.

Product Categories/Family for anti-MOG antibody

Antibodies; Myelin

References

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 2. Boyle, L.H., et al. J. Neurochem. 102(6):1853-1862(2007). 3. Allamargot, C., et al. J. Neurochem. 101(2):298-312(2007). 4. Delarasse, C., et al. J. Neurochem. 98(6):1707-1717(2006). 5. Ballenthin, P.A., et al. J. Neurosci. Res. 46(2):271-281(1996).

NCBI and Uniprot Product Information

• NCBI GI #: 56788389
• NCBI GeneID: 4340
• NCBI Accession #: NP_001008229.1
• NCBI GenBank Nucleotide #: NM_001008228.2
• UniProt Accession #: Q16653; O00713; O00714; O00715; Q13054; Q13055; A6NDR4; A6NNJ9; A8MY31; B0UZR9; E9PGF0; F8W9D5
• Molecular Weight: 33,528 Da
• NCBI Official Full Name: myelin-oligodendrocyte glycoprotein isoform alpha3
• NCBI Official Synonym Full Names: myelin oligodendrocyte glycoprotein
• NCBI Official Symbol: MOG
• NCBI Official Synonym Symbols: BTN6; BTNL11; MOGIG2; NRCLP7
• NCBI Protein Information: myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5
• UniProt Protein Name: Myelin-oligodendrocyte glycoprotein
• Protein Family: Molybdopterin adenylyltransferase
• UniProt Gene Name: MOG
• UniProt Entry Name: MOG_HUMAN

NCBI Description

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: plasma membrane; integral to membrane

Biological Process: central nervous system development; positive regulation of MyD88-dependent toll-like receptor signaling pathway; cell adhesion

Disease: Narcolepsy 7