Rabbit anti-Human MOCS2 Polyclonal Antibody | anti-MOCS2 antibody

MOCS2, NT (MOCS2, MCBPE, MOCO1, Molybdopterin synthase catalytic subunit, MOCO1-B, Molybdenum cofactor synthesis protein 2 large subunit, Molybdenum cofactor synthesis protein 2B, Molybdopterin-synthase large subunit)

Cat. Num. AAA6011761

• Gene Names: MOCS2; MPTS; MCBPE; MOCO1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: MOCS2; Polyclonal Antibody; NT (MOCS2; MCBPE; MOCO1; Molybdopterin synthase catalytic subunit; MOCO1-B; Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2B; Molybdopterin-synthase large subunit); Anti -MOCS2; anti-MOCS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-MOCS2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: MOCS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-43 amino acids from the N-terminal region of human MOCS2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(MOCS2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MOCS2 antibody detected the MOCS2 protein (arrow).)

Related Product Information for anti-MOCS2 antibody

Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits.

Product Categories/Family for anti-MOCS2 antibody

Antibodies; Abs to Enzymes; Synthase

NCBI and Uniprot Product Information

• NCBI GI #: 28631173
• NCBI GeneID: 4338
• NCBI Accession #: NP_789776.1
• NCBI GenBank Nucleotide #: NM_176806.3
• UniProt Accession #: O96033; O96007
• Molecular Weight: 9,755 Da
• NCBI Official Full Name: molybdopterin synthase sulfur carrier subunit small subunit MOCS2A
• NCBI Official Synonym Full Names: molybdenum cofactor synthesis 2
• NCBI Official Symbol: MOCS2
• NCBI Official Synonym Symbols: MPTS; MCBPE; MOCO1
• NCBI Protein Information: molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit; molybdenum cofactor biosynthesis protein E; molybdopterin synthase small and large subunit
• UniProt Protein Name: Molybdopterin synthase sulfur carrier subunit
• UniProt Gene Name: MOCS2
• UniProt Synonym Gene Names: MOCO1; MOCS2A
• UniProt Entry Name: MOC2A_HUMAN

NCBI Description

Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]

Uniprot Description

MOCS2 iso2: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Defects in MOCS2 are the cause of molybdenum cofactor deficiency type B (MOCOD type B). MOCOD type B is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Belongs to the MoaE family. MOCS2B subfamily.

Protein type: EC 2.8.1.12; Enzyme, misc.

Chromosomal Location of Human Ortholog: 5q11

Cellular Component: molybdopterin synthase complex; cytoplasm; nucleus; cytosol

Molecular Function: identical protein binding; nucleotide binding; Mo-molybdopterin synthase activity

Biological Process: vitamin metabolic process; Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process; water-soluble vitamin metabolic process

Disease: Molybdenum Cofactor Deficiency, Complementation Group A