Rabbit MOBKL1B Polyclonal Antibody | anti-MOBKL1B antibody

MOBKL1B Antibody

Cat. Num. AAA9603985

• Gene Names: MOB1A; MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: MOBKL1B; Polyclonal Antibody; MOBKL1B Antibody; B1; Mps One Binder kinase activator like 1B (yeast); C2orf6; Chromosome 2 open reading frame 6; FLJ10788; FLJ11595; MATS1; MOB kinase activator 1A; MOB1; Mob1 alpha; Mob1 homolog 1B; MOB1 Mps One Binder homolog A; MOB1 Mps One Binder kinase activator like 1B; Mob1A; MOB4B; Mob4B protein; MOBK1B; Mobkl1b; MOL1B_HUMAN; Mps one binder kinase activator like 1B; Mps one binder kinase activator-like 1B; Protein Mob4B; anti-MOBKL1B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MOBKL1B antibody detects endogenous levels of total MOBKL1B
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 215

• Applicable Applications for anti-MOBKL1B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide
• Tissue Specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.
• Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
• Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (89%), Xenopus (89%)
• Conjugation: Unconjugated

Western Blot (WB)

(Western blot analysis of MOBKL1B expression in A431 whole cell lysate, The lane on the left is treated with the antigen-specific peptide.)

Related Product Information for anti-MOBKL1B antibody

Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
Subunit Structure: Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.
Post-translational Modifications: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
Similarity: Belongs to the MOB1/phocein family.

NCBI and Uniprot Product Information

• NCBI GI #: 952977832
• NCBI GeneID: 55233
• NCBI Accession #: NP_001304039.1
• NCBI GenBank Nucleotide #: NM_001317110.1
• UniProt Accession #: Q9H8S9; Q53S34; Q9H3T5; Q9HAI0; Q9NVE2
• Molecular Weight: Observed: 25 kDa; Predicted: 26 kDa
• NCBI Official Full Name: MOB kinase activator 1A isoform 2
• NCBI Official Synonym Full Names: MOB kinase activator 1A
• NCBI Official Symbol: MOB1A
• NCBI Official Synonym Symbols: MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B
• NCBI Protein Information: MOB kinase activator 1A
• UniProt Protein Name: MOB kinase activator 1A
• UniProt Gene Name: MOB1A
• UniProt Synonym Gene Names: C2orf6; MOB4B; MOBK1B; MOBKL1B; Mob1A

NCBI Description

The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.