Rabbit anti-Human MOAP1 Polyclonal Antibody | anti-MOAP1 antibody
MOAP1 Antibody
Gene Names
MOAP1; MAP-1; PNMA4
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
MOAP1; Polyclonal Antibody; MOAP1 Antibody; MAP 1; MAP-1; MAP1; MOAP1_HUMAN; Modulator of apoptosis 1; Modulator of Apoptosis; Paraneoplastic antigen like 4; Paraneoplastic antigen Ma4; paraneoplastic Ma antigen family member 4; PNMA4; anti-MOAP1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
MOAP1 Antibody detects endogenous levels of MOAP1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-MOAP1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human MOAP1.
Conjugation
Unconjugated
Similarity
The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction. Belongs to the PNMA family.
Post Translational Modifications
Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.
Subunit Structure
Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Interacts with TRIM39. Interacts with RASSF6 (By similarity).
Tissue Specificity
Widely expressed, with high levels in heart and brain.
Function
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-MOAP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,513 Da
NCBI Official Full Name
modulator of apoptosis 1
NCBI Official Synonym Full Names
modulator of apoptosis 1
NCBI Official Symbol
MOAP1
NCBI Official Synonym Symbols
MAP-1; PNMA4
NCBI Protein Information
modulator of apoptosis 1; MAP1; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen like 4
UniProt Protein Name
Modulator of apoptosis 1
Protein Family
UniProt Gene Name
MOAP1
UniProt Synonym Gene Names
PNMA4; MAP-1; MAP1
UniProt Entry Name
MOAP1_HUMAN
NCBI Description
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Description
MOAP1: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Belongs to the PNMA family.
Chromosomal Location of Human Ortholog: 14q32
Cellular Component: mitochondrial outer membrane; mitochondrion; cytoplasm; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; protein insertion into mitochondrial membrane during induction of apoptosis; positive regulation of apoptosis
Research Articles on MOAP1
Similar Products
Product Notes
The MOAP1 moap1 (Catalog #AAA9629795) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MOAP1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MOAP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the MOAP1 moap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MOAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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