Rabbit MNX1/HLXB9 Polyclonal Antibody | anti-MNX1/HLXB9 antibody

MNX1/HLXB9 Polyclonal Antibody

Cat. Num. AAA3015217

• Gene Names: MNX1; HB9; HLXB9; SCRA1; HOXHB9
• Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit
• Applications: Flow Cytometry, Functional Assay
• Purity: affinity purified by Protein A
• Synonyms: MNX1/HLXB9; Polyclonal Antibody; MNX1/HLXB9 Polyclonal Antibody; HB9/HLXB9; HB 9; HB9; HLXB 9; HLXB9; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; MNX1_HUMAN; Motor neuron and pancreas homeobox protein 1; Sacral agenesis autosomal dominant (Currarino triad); SCRA 1; SCRA1; anti-MNX1/HLXB9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit
• Clonality: Polyclonal
• Specificity: MNX1/HLXB9 Polyclonal Antibody detects endogenous levels of MNX1/HLXB9 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-MNX1/HLXB9 antibody: Flow Cytometry (FC/FACS/FCM)
• Application Notes: FC/FACS/FCM: 1ug/Test
• Immunogen: KLH conjugated synthetic peptide derived from human HLXB9
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Related Product Information for anti-MNX1/HLXB9 antibody

The HB9 homeobox transcription factor regulates gene expression during embryonic development and also in specific adult tissues. HB9 gene mutations are implicated in Curriano syndrome, which is characterized by a triad consisting of a presacral tumor, sacral agenesis and anorectal malformation. In human bone marrow cells, HB9 expression directly correlates with CD34 expression. Furthermore, HB9 expression increases in CD34+ cells that are treated with IL-3 and granulocyte macrophage-colony-stimulating factor. Early in murine development, HB9 is expressed in pancreatic buds (dorsal and ventral) with subsequent expression in differentiating beta cells in the islets of Langerhans. The dorsal lobe of the pancreas fails to form in HB9(-) mice; the resultant pancreas has smaller islets of Langerhans and less beta cells than normal pancreas. The HB9 gene is expressed in the human adult pancreas. In the developing vertebrate embryo, the HB9 gene plays an essential role in motor neuron differentiation. The motor columns of HB9(-) mice are disorganized, lacking phrenic and abducens nerves and exhibiting intercostal nerve defects.

NCBI and Uniprot Product Information

• NCBI GI #: 119624969
• NCBI GeneID: 3110
• UniProt Accession #: P50219; Q9Y648; F5H401
• Molecular Weight: 40,569 Da
• NCBI Official Full Name: homeobox HB9
• NCBI Official Synonym Full Names: motor neuron and pancreas homeobox 1
• NCBI Official Symbol: MNX1
• NCBI Official Synonym Symbols: HB9; HLXB9; SCRA1; HOXHB9
• NCBI Protein Information: motor neuron and pancreas homeobox protein 1; homeobox HB9; homeobox protein HB9
• UniProt Protein Name: Motor neuron and pancreas homeobox protein 1
• UniProt Gene Name: MNX1
• UniProt Synonym Gene Names: HLXB9
• UniProt Entry Name: MNX1_HUMAN

NCBI Description

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; anatomical structure morphogenesis; transcription, DNA-dependent; spinal cord motor neuron cell fate specification; neuron migration; nerve development; motor axon guidance; endocrine pancreas development; dorsoventral neural tube patterning; humoral immune response; post-embryonic development

Disease: Currarino Syndrome