Rabbit anti-Human MMP7 Polyclonal Antibody | anti-MMP7 antibody

Anti-MMP7 Antibody

Cat. Num. AAA176931

• Gene Names: MMP7; MMP-7; MPSL1; PUMP-1
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Immunogen affinity purified.
• Synonyms: MMP7; Polyclonal Antibody; Anti-MMP7 Antibody; Matrilysin; matrix metallopeptidase 7 (matrilysin; uterine); Matrilysin antibody; Matrilysin uterine antibody; Matrin antibody; Matrix Metalloproteinase 7 antibody; Matrix metalloproteinase-7 antibody; MMP 7 antibody; MMP-7 antibody; MMP7 antibody; MMP7_HUMAN antibody; MPSL1 antibody; PUMP 1 antibody; Pump 1 protease antibody; Pump-1 protease antibody; PUMP1 antibody; Uterine Matrilysin antibody; Uterine metalloproteinase antibody; anti-MMP7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 267

• Applicable Applications for anti-MMP7 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
• Immunogen: E Coli-derived human MMP7 recombinant protein (Position: M1-K267). Human MMP7 shares 71% amino acid (aa) sequences identity with both mouse and rat MMP7.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-MMP7 Picoband antibody, MBS176931-1.JPGIHC(P): Human Intestinal Cancer Tissue )

Immunohistochemistry (IHC)

(Anti-MMP7 Picoband antibody, MBS176931-2.JPGIHC(P): Human Placenta Tissue )

Western Blot (WB)

(Anti-MMP7 Picoband antibody, MBS176931-3.jpgAll lanes: Anti-MMP7(MBS176931) at 0.5ug/mlWB: A549 Whole Cell Lysate at 40ugPredicted bind size: 30KDObserved bind size: 30KD )

Related Product Information for anti-MMP7 antibody

Description: Rabbit IgG polyclonal antibody for Matrilysin(MMP7) detection. Tested with WB, IHC-P, ELISA in Human.
Background: Matrix metalloproteinase-7 (MMP-7) previously called putative metalloproteinase I (PUMP1) or matrilysin. The MMP-7 gene has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The MMP-7 protein has 267 amino acids and is significantly shorter than stromelysin or collagenase (477 and 469 amino acids, respectively). Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. MMP-7, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, MMP-7 mRNA is regulated in a specific and distinct manner in normal and malignant tissues. MMP-7 has been shown to correlate with nodal or distant metastasis in colorectal carcinomas, however, its implication in early invasive colorectal carcinomas has not been determined. MMP-7 is also a mediator of pulmonary fibrosis and a potential therapeutic target. The standard product used in this kit is recombinant human MMP-7, consisting of 250 amino acids with the molecular mass of 28KDa. The detected MMP-7 includes zymogen and active enzyme.

NCBI and Uniprot Product Information

• NCBI GI #: 116861
• NCBI GeneID: 4316
• UniProt Accession #: P09237; Q9BTK9
• Molecular Weight: 29,677 Da
• NCBI Official Full Name: Matrilysin
• NCBI Official Synonym Full Names: matrix metallopeptidase 7 (matrilysin, uterine)
• NCBI Official Symbol: MMP7
• NCBI Official Synonym Symbols: MMP-7; MPSL1; PUMP-1
• NCBI Protein Information: matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine)
• UniProt Protein Name: Matrilysin
• Protein Family: Matrilysin
• UniProt Gene Name: MMP7
• UniProt Synonym Gene Names: MPSL1; PUMP1; MMP-7
• UniProt Entry Name: MMP7_HUMAN

NCBI Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Uniprot Description

MMP7: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family.

Protein type: Secreted; Secreted, signal peptide; Protease; EC 3.4.24.23

Chromosomal Location of Human Ortholog: 11q22.2

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity

Biological Process: response to drug; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to Gram-positive bacterium; antibacterial peptide biosynthetic process; defense response to Gram-negative bacterium; proteolysis; antibacterial peptide secretion; regulation of cell proliferation