Western Blot (WB)
(MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow).)
Rabbit anti-Human MKL1 Polyclonal Antibody | anti-MKL1 antibody
MKL1 Antibody (Center)
Western Blot (WB)
(MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow).)
Western Blot (WB)
(MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow).)
transcription factor myocardin, a key regulator of smooth muscle
cell differentiation. The encoded protein is predominantly nuclear
and may help transduce signals from the cytoskeleton to the
nucleus. This gene is involved in a specific translocation event
that creates a fusion of this gene and the RNA-binding motif
protein-15 gene. This translocation has been associated with acute
megakaryocytic leukemia.
Hinohara, K., et al. Hum. Genet. 126(4):539-547(2009)
Estrada, K., et al. Hum. Mol. Genet. 18(18):3516-3524(2009)
Brandt, D.T., et al. Nat. Cell Biol. 11(5):557-568(2009)
Medjkane, S., et al. Nat. Cell Biol. 11(3):257-268(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Description
MKL1: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation. Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2. Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.
Protein type: Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q13
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: actin monomer binding; protein binding; leucine zipper domain binding; transcription coactivator activity; actin binding; transcription factor activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; negative regulation of caspase activity
Research Articles on MKL1
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Product Notes
The MKL1 mkl1 (Catalog #AAA9208528) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 497-525. The MKL1 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MKL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MKL1 mkl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MKL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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