Rabbit anti-Human Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Polyclonal Antibody | anti-MAP2K4 antibody

APC/CY7-Linked Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4)

Cat. Num. AAA2071893

• Gene Names: MKK4; ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4; ATMEK4; ATMKK4; F19C24.26; F19C24_26; MAP KINASE KINASE 4; mitogen-activated protein kinase kinase 4
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA
• Synonyms: Mitogen Activated Protein Kinase Kinase 4 (MAP2K4); Polyclonal Antibody; APC/CY7-Linked Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4); JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; c-Jun N-terminal kinase kinase 1; JNK-activating kinase 1; Stress-activated protein kinase kinase 1; anti-MAP2K4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Concentration: >=100ug/ml (varies by lot)

• Applicable Applications for anti-MAP2K4 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
• Immunogen: MAP2K4 (Val137~Ser394)
• Conjugation: APC-Cy7
• Cross Reactivity: Human
• Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2004006

NCBI and Uniprot Product Information

• NCBI GI #: 15217998
• NCBI GeneID: 841591
• NCBI Accession #: NP_175577.1
• NCBI GenBank Nucleotide #: NM_104044.3
• UniProt Accession #: O80397
• Molecular Weight: 40,117 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase 4
• NCBI Official Symbol: MKK4
• NCBI Official Synonym Symbols: ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4; ATMEK4; ATMKK4; F19C24.26; F19C24_26; MAP KINASE KINASE 4; mitogen-activated protein kinase kinase 4
• NCBI Protein Information: mitogen-activated protein kinase kinase 4
• UniProt Protein Name: Mitogen-activated protein kinase kinase 4
• Protein Family: Dual specificity mitogen-activated protein kinase kinase
• UniProt Gene Name: MKK4
• UniProt Synonym Gene Names: AtMKK4; MAP kinase kinase 4

NCBI Description

Encodes a mitogen-activated map kinase kinase (there are nine in Arabidopsis) involved in innate immunity. This protein activates MPK3/MPK6 and early-defense genes redundantly with MKK5. In plants with both MKK5 and MKK6 levels reduced by RNAi plants, floral organs do not abscise suggestion a role for both proteins in mediating floral organ abscission.

Uniprot Description

Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs. MKK4 and MKK5 participate in the regulation of floral organ abscission. Mediates osmotic-stress response via its regulation of MPK3 activity. Target of the Pseudomonas syringae type III effector HopF2.