Rabbit anti-Human MIP3B Polyclonal Antibody | anti-MIP3B antibody

MIP3B, CT (C-C Motif Chemokine 19, Small Inducible Cytokine A19, Macrophage Inflammatory Protein 3 beta, MIP-3-beta, Epstein-Barr Virus-induced Molecule 1 Ligand Chemokine, EBI1-ligand Chemokine, ELC, Beta Chemokine Exodus-3, CK beta-11, CCL19, SCYA19) (M

Cat. Num. AAA6486019

• Gene Names: CCL19; ELC; CKb11; MIP3B; MIP-3b; SCYA19
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: MIP3B; Polyclonal Antibody; CT (C-C Motif Chemokine 19; Small Inducible Cytokine A19; Macrophage Inflammatory Protein 3 beta; MIP-3-beta; Epstein-Barr Virus-induced Molecule 1 Ligand Chemokine; EBI1-ligand Chemokine; ELC; Beta Chemokine Exodus-3; CK beta-11; CCL19; SCYA19) (M; anti-MIP3B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CCL19.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-MIP3B antibody: Immunohistochemistry (IHC), FLISA
• Application Notes: IHC: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human CCL19 (KLH).
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-MIP3B antibody

Antibodies; Growth Factors; Cytokines

References

1. Townson, J.R., et al., Eur. J. Immunol. 32(5):1230-1241 (2002). 2. Till, K.J., et al., Blood 99(8):2977-2984 (2002). 3. Phillips, R., et al., Eur. J. Immunol. 32(3):837-847 (2002). 4. Ueno, T., et al., Immunity 16(2):205-218 (2002). 5. Kim, C.H., et al., J. Immunol. 160(5):2418-2424 (1998).

NCBI and Uniprot Product Information

• NCBI GI #: 5454040
• NCBI GeneID: 6363
• NCBI Accession #: NP_006265
• NCBI GenBank Nucleotide #: NM_006274.2
• UniProt Accession #: Q99731; O00697; O00736
• Molecular Weight: 10.4 kDa (93aa) confirmed by MALDI-TOF
• NCBI Official Full Name: C-C motif chemokine 19
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 19
• NCBI Official Symbol: CCL19
• NCBI Official Synonym Symbols: ELC; CKb11; MIP3B; MIP-3b; SCYA19
• NCBI Protein Information: C-C motif chemokine 19
• UniProt Protein Name: C-C motif chemokine 19
• UniProt Gene Name: CCL19
• UniProt Synonym Gene Names: ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta
• UniProt Entry Name: CCL19_HUMAN

NCBI Description

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR chemokine receptor binding; chemokine receptor binding; chemokine activity; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding

Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; activation of JNK activity; positive regulation of receptor-mediated endocytosis; dendritic cell chemotaxis; cell communication; positive regulation of T cell proliferation; establishment of T cell polarity; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation