Immunohistochemistry (IHC)
(Immunochemical staining of human MIOX in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human MIOX Polyclonal Antibody | anti-MIOX antibody
Anti-MIOX Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
MIOX; Polyclonal Antibody; Anti-MIOX Antibody; Rabbit Polyclonal; MIOX Antibody; Rabbit PAb; Antigen Affinity Purified; myo-inositol oxygenase; Anti-ALDRL6 Antibody; anti-MIOX antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human MIOX
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-MIOX antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human MIOX fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human MIOX fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human MIOX in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human MIOX in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-MIOX antibody
The enzyme Myo-inositol oxygenase (MIOX) is also termed ALDRL6. It is a kidney-specific member of the Aldo-keto reductase family. MIOX is the first enzyme in the inositol route to ascorbate (L-ascorbic acid, ASA, vitamin C). MIOX catalyzes the oxidative cleavage of Myo-inositol (MI) to give D-glucuronic acid, a committed step in MI catabolism. MIOX catalyzes the first reaction involved in the Myo-inositol metabolism signaling pathway and is fully expressed in mammalian tissues. MIOX catalyzes the oxidative cleavage of myo-Inositol and its epimer, D-chiro-inositol to D-glucuronate. The dioxygen-dependent cleavage of the C6 and C1 bond in Myo-inositol is achieved by utilizing the Fe2+/Fe3+ binuclear iron center of MIOX. This enzyme has also been implicated in the complications of diabetes, including diabetic nephropathy. Overexpression of Myo-inositol oxygenase (MIOX), a proximal tubular enzyme, exacerbates cellular redox injury in acute kidney injury (AKI).
References
Nepal N, et al. (2019) Mechanisms underlying the enhanced biomass and abiotic stress tolerance phenotype of an arabidopsis miox over-expresser. Plant Direct 3 (9): e00165.Lu Y, et al. (2009) Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy. Exp Clin Endocrinol Diabetes 117 (6): 257-265.Gonzalez-Alvarez R, et al. (2017) Molecular cloning of the myo-inositol oxygenase gene from the kidney of baboons. Biomed Rep 7 (4): 301-305.Gaut JP, et al. (2014) Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem 60 (5): 747-757.
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Product Notes
The MIOX (Catalog #AAA8109130) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MIOX Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MIOX can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the MIOX for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MIOX, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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