Rabbit anti-Human MINK1, 2 Polyclonal Antibody | anti-MINK antibody

MINK1, 2, CT (Misshapen/NIK-related Kinase, Misshapen-like Kinase 1, MINK1, MINK, B55, GCK Family Kinase MiNK, hMINK, hMINKbeta, MAPK/ERK Kinase Kinase Kinase 6, MEK Kinase Kinase 6, MEKKK 6, Mitogen-activated Protein Kinase Kinase Kinase Kinase 6, MAP4K6

Cat. Num. AAA6488203

• Gene Names: MINK1; B55; ZC3; MINK; YSK2; hMINK; MAP4K6; hMINKbeta
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: MINK1; 2; Polyclonal Antibody; CT (Misshapen/NIK-related Kinase; Misshapen-like Kinase 1; MINK; B55; GCK Family Kinase MiNK; hMINK; hMINKbeta; MAPK/ERK Kinase Kinase Kinase 6; MEK Kinase Kinase 6; MEKKK 6; Mitogen-activated Protein Kinase Kinase Kinase Kinase 6; MAP4K6; EC=2.7.11.1; MGC21111; anti-MINK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MINK1/2.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-MINK antibody: Immunohistochemistry (IHC), FLISA
• Application Notes: IHC: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human MINK1/2 (KLH).
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-MINK antibody

Antibodies; Protein Kinases

References

1. Strausberg, R.L., et al., Proc. Natl. Acad. Sci. USA 99(26):16899-16903 (2002). 2. Dan, I., et al., FEBS Lett. 469(1):19-23 (2000).

NCBI and Uniprot Product Information

• NCBI GI #: 68161546
• NCBI GeneID: 50488
• NCBI Accession #: NP_001020108.1
• NCBI GenBank Nucleotide #: NM_001024937.3
• UniProt Accession #: Q8N4C8; Q5U8Z0; Q9P1X1; Q9P2R8; D3DTK3; D3DTK4
• Molecular Weight: 149,822 Da
• NCBI Official Full Name: misshapen-like kinase 1 isoform 4
• NCBI Official Synonym Full Names: misshapen-like kinase 1
• NCBI Official Symbol: MINK1
• NCBI Official Synonym Symbols: B55; ZC3; MINK; YSK2; hMINK; MAP4K6; hMINKbeta
• NCBI Protein Information: misshapen-like kinase 1; MEKKK 6; MEK kinase kinase 6; GCK family kinase MINK; misshapen/NIK-related kinase; MAPK/ERK kinase kinase kinase 6; serine/threonine protein kinase; mitogen-activated protein kinase kinase kinase kinase 6
• UniProt Protein Name: Misshapen-like kinase 1
• UniProt Gene Name: MINK1
• UniProt Synonym Gene Names: B55; MAP4K6; MINK; YSK2; ZC3; MEK kinase kinase 6; MEKKK 6
• UniProt Entry Name: MINK1_HUMAN

NCBI Description

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; MSN subfamily

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: Golgi apparatus; postsynaptic membrane; axon; dendrite; cytoplasm; postsynaptic density; cell junction; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: regulation of cell-matrix adhesion; multicellular organismal development; protein amino acid autophosphorylation; dendrite morphogenesis; positive regulation of JNK cascade; negative thymic T cell selection; regulation of cell migration; protein amino acid phosphorylation; microvillus biogenesis; synaptic transmission; regulation of cell-cell adhesion; regulation of catalytic activity; actin cytoskeleton reorganization; JNK cascade; response to stress