Western Blot (WB)
(Western Blot analysis of 293 cell line lysates (35ug/lane) using MBS626620 (arrow) was detected using the purified Pab.)
Rabbit anti-Human METAP2 Polyclonal Antibody | anti-METAP2 antibody
METAP2, NT (Methionine Aminopeptidase 2, MetAP 2, MAP 2, Peptidase M 2, Initiation Factor 2-associated 67kD Glycoprotein, p67eIF2)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: ELISA: 1:1000
Western Blot: 1:100-1:500
Western Blot (WB)
(Western Blot analysis of 293 cell line lysates (35ug/lane) using MBS626620 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western Blot analysis of 293 cell line lysates (35ug/lane) using MBS626620 (arrow) was detected using the purified Pab.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq]
Uniprot Description
METAP2: Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Interacts strongly with the eIF-2 gamma-subunit EIF2S3. Binds EIF2S1 at low magnesium concentrations. Belongs to the peptidase M24A family.
Protein type: EC 3.4.11.18; Protease
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: metalloexopeptidase activity; metal ion binding; aminopeptidase activity
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; peptidyl-methionine modification; protein processing; proteolysis; N-terminal protein amino acid modification
Research Articles on METAP2
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Product Notes
The METAP2 metap2 (Catalog #AAA626620) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The METAP2, NT (Methionine Aminopeptidase 2, MetAP 2, MAP 2, Peptidase M 2, Initiation Factor 2-associated 67kD Glycoprotein, p67eIF2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's METAP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:1000 Western Blot: 1:100-1:500. Researchers should empirically determine the suitability of the METAP2 metap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "METAP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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