Rabbit Melatonin Receptor 1A/MTNR1A Polyclonal Antibody | anti-1A/MTNR1A antibody

Melatonin Receptor 1A/MTNR1A Rabbit pAb

Cat. Num. AAA4758743

• Gene Names: MTNR1A; MT1; MEL-1A-R
• Reactivity: Human, Mouse, Rat
• Applications: Immunocytochemistry, Immunofluorescence, ELISA
• Purity: Affinity purified
• Synonyms: Melatonin Receptor 1A/MTNR1A; Polyclonal Antibody; Melatonin Receptor 1A/MTNR1A Rabbit pAb; MTNR1A; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor; anti-1A/MTNR1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applicable Applications for anti-1A/MTNR1A antibody: Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: WB: 1:500-2000
• Immunogen: synthesized peptide of human MTR1A. AA range:191-240
• Conjugation: Unconjugated
• Modification: Unmodified
• Cell Position: plasma membrane, integral component of plasma membrane, integral component of membrane, receptor complex
• Preparation and Storage: Store at 2-8 degree C for short term, aliquot and store at -20 degree C for long term.Avoid freeze/thaw cycles

Immunofluorescence (IF)

(Immunofluorescence analysis of CD31 in HepG2 cells using MTR1A Antibody. The picture on the right is blocked with synthesized peptide.)

Related Product Information for anti-1A/MTNR1A antibody

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Product Categories/Family for anti-1A/MTNR1A antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 5174593
• NCBI GeneID: 4543
• NCBI Accession #: NP_005949.1
• NCBI GenBank Nucleotide #: NM_005958.3
• UniProt Accession #: P48039; A0AVC5; B0M0L2
• Molecular Weight: 39,375 Da
• NCBI Official Full Name: melatonin receptor type 1A
• NCBI Official Synonym Full Names: melatonin receptor 1A
• NCBI Official Symbol: MTNR1A
• NCBI Official Synonym Symbols: MT1; MEL-1A-R
• NCBI Protein Information: melatonin receptor type 1A; mel1a receptor
• UniProt Protein Name: Melatonin receptor type 1A
• UniProt Gene Name: MTNR1A
• UniProt Synonym Gene Names: Mel-1A-R
• UniProt Entry Name: MTR1A_HUMAN

NCBI Description

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Uniprot Description

MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; hormone binding; melatonin receptor activity

Biological Process: circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cGMP biosynthetic process; mating behavior