Western Blot (WB)
(Western blot analysis of extracts from Hela cell untreated or treated with UV MEK1/MEK2 (Phospho-Ser217/Ser221) Antibody)
Rabbit MEK1/MEK2 Polyclonal Antibody | anti-MEK1/MEK2 antibody
Anti-MEK1/MEK2 (Phospho-Ser217/Ser221) Rabbit pAb
IHC: 1:50-1:100
Western Blot (WB)
(Western blot analysis of extracts from Hela cell untreated or treated with UV MEK1/MEK2 (Phospho-Ser217/Ser221) Antibody)
Western Blot (WB)
(Western blot analysis of extracts from Hela cell untreated or treated with UV MEK1/MEK2 (Phospho-Ser217/Ser221) Antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MEK1/MEK2 (Phospho-Ser217/Ser221) Antibody (left) or the same antibody preincubated with blocking peptide (right).)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MEK1/MEK2 (Phospho-Ser217/Ser221) Antibody (left) or the same antibody preincubated with blocking peptide (right).)
UniPort Summary Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Uniprot Description
MEK1: a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf, Mos and Cot kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK1 and ERK2. An essential component of MAP kinase signal transduction pathways involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytoplasm; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; mitochondrion; nucleus; plasma membrane
Molecular Function: MAP kinase kinase activity; protein binding; protein C-terminus binding; protein kinase activity; protein N-terminus binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; cell cycle arrest; cell motility; chemotaxis; MAPKKK cascade; negative regulation of cell proliferation; positive regulation of transcription, DNA-dependent; regulation of stress-activated MAPK cascade; signal transduction
Disease: Cardiofaciocutaneous Syndrome 3; Noonan Syndrome 1
Research Articles on MEK1/MEK2
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Product Notes
The MEK1/MEK2 map2k1 (Catalog #AAA477014) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MEK1/MEK2 (Phospho-Ser217/Ser221) Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MEK1/MEK2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). WB: 1:500-1:1000 IHC: 1:50-1:100. Researchers should empirically determine the suitability of the MEK1/MEK2 map2k1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MEK1/MEK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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