Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placental tissue using MBS7049755 at dilution of 1:100)
Rabbit anti-Human MEIKIN Polyclonal Antibody | anti-MEIKIN antibody
MEIKIN Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placental tissue using MBS7049755 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placental tissue using MBS7049755 at dilution of 1:100)
NCBI and Uniprot Product Information
Uniprot Description
MEIKIN: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono- orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichemnt to kinetochores. Not required during meiosis II or mitosis. {ECO:0000250|UniProtKB:Q5F2C3}. Interacts with CENPC. Interacts with PLK1; required for recruitment of PLK1 at kinetochores. {ECO:0000250|UniProtKB:Q5F2C3}
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: condensed nuclear chromosome, pericentric region
Biological Process: female meiosis chromosome segregation; homologous chromosome segregation; male meiosis chromosome segregation; meiotic sister chromatid cohesion, centromeric
Research Articles on MEIKIN
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Product Notes
The MEIKIN meikin (Catalog #AAA7049755) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MEIKIN Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MEIKIN can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1: 20-1: 200. Researchers should empirically determine the suitability of the MEIKIN meikin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MEIKIN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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