Rabbit anti-Human, Mouse MEF2C Polyclonal Antibody | anti-MEF2C antibody

MEF2C Polyclonal Antibody

Cat. Num. AAA2554068

• Gene Names: MEF2C; DEL5q14.3; C5DELq14.3
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: MEF2C; Polyclonal Antibody; MEF2C Polyclonal Antibody; C5DELq14.3; DEL5q14.3; MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C); Myocyte enhancer factor 2C; Myocyte specific enhancer factor 2C; OTTHUMP00000222409; Similar to MADS box transcription enhancer factor 2 polypeptide C; anti-MEF2C antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
• Concentration: 2 mg/mL (varies by lot)
• Sequence Length: 465

• Applicable Applications for anti-MEF2C antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant Human Myocyte-specific enhancer factor 2C protien
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lymph node using MEF-2C Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Mouse brain using MEF-2C Polyclonal Antibody at dilution of 1:200)

Related Product Information for anti-MEF2C antibody

This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.

Product Categories/Family for anti-MEF2C antibody

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Neuroscience; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 196114945
• NCBI GeneID: 4208
• NCBI Accession #: NP_001124477.1
• NCBI GenBank Nucleotide #: NM_001131005.2
• UniProt Accession #: Q06413; C9JMZ0; D7F7N5; F8W7V7
• Molecular Weight: 50,336 Da
• NCBI Official Full Name: myocyte-specific enhancer factor 2C isoform 2
• NCBI Official Synonym Full Names: myocyte enhancer factor 2C
• NCBI Official Symbol: MEF2C
• NCBI Official Synonym Symbols: DEL5q14.3; C5DELq14.3
• NCBI Protein Information: myocyte-specific enhancer factor 2C
• UniProt Protein Name: Myocyte-specific enhancer factor 2C
• Protein Family: Myocyte-specific enhancer factor
• UniProt Gene Name: MEF2C

NCBI Description

This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

Uniprot Description

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.