Mouse anti-Human, Mouse MEF2C Monoclonal Antibody | anti-MEF2C antibody

Anti-MEF2C Mouse mAb

Cat. Num. AAA476376

• Gene Names: MEF2C; DEL5q14.3; C5DELq14.3
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
• Synonyms: MEF2C; Monoclonal Antibody; Anti-MEF2C Mouse mAb; DEL5q14.3; C5DELq14.3; anti-MEF2C antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 6H2G2
• Form/Format: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
• Sequence Length: 101

• Applicable Applications for anti-MEF2C antibody: Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Immunogen: Purified recombinant fragment of human MEF2C (AA: 1-125) expressed in E Coli.

Western Blot (WB)

(Western blot analysis using MEF2C mAb against human MEF2C recombinant protein. (Expected MW is 40 kDa))

Western Blot (WB)

(Western blot analysis using MEF2C mAb against HEK293 (1) and MEF2C (AA)

Western Blot (WB)

(Western blot analysis using MEF2C mouse mAb against NIH3T3 (1) and 3T3-L1 (2) cell lysate.)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of HeLa cells using MEF2C mouse mAb (green) and negative control (purple).)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded colon cancer tissues using MEF2C mouse mAb with DAB staining.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using MEF2C mouse mAb with DAB staining.)

Related Product Information for anti-MEF2C antibody

Entrez Summary: This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 958834217
• NCBI GeneID: 4208
• Molecular Weight: 51.2
• NCBI Official Full Name: MEF2C, partial
• NCBI Official Synonym Full Names: myocyte enhancer factor 2C
• NCBI Official Symbol: MEF2C
• NCBI Official Synonym Symbols: DEL5q14.3; C5DELq14.3
• NCBI Protein Information: myocyte-specific enhancer factor 2C
• UniProt Protein Name: Myocyte-specific enhancer factor 2C
• Protein Family: Myocyte-specific enhancer factor
• UniProt Gene Name: MEF2C

NCBI Description

This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

Uniprot Description

MEF2C: transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q14.3

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus; protein complex

Molecular Function: AT DNA binding; miRNA binding; protein binding; protein heterodimerization activity; transcription activator binding; transcription factor activity

Biological Process: B cell homeostasis; B cell proliferation; B cell receptor signaling pathway; blood vessel development; blood vessel remodeling; chondrocyte differentiation; endochondral ossification; germinal center formation; heart development; heart looping; humoral immune response; learning and/or memory; MAPKKK cascade; melanocyte differentiation; muscle cell fate determination; muscle development; myotube differentiation; negative regulation of neuron apoptosis; negative regulation of ossification; negative regulation of transcription from RNA polymerase II promoter; nervous system development; neural crest cell differentiation; neuron development; neuron differentiation; neuron migration; neuron morphogenesis during differentiation; osteoblast differentiation; platelet formation; positive regulation of B cell proliferation; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of excitatory postsynaptic membrane potential; regulation of germinal center formation; regulation of megakaryocyte differentiation; regulation of neuron apoptosis; regulation of neurotransmitter secretion; regulation of synaptic activity; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; regulation of synaptogenesis; regulation of transcription, DNA-dependent; response to virus; skeletal muscle development; smooth muscle cell differentiation; ventricular cardiac muscle cell differentiation

Disease: Mental Retardation, Autosomal Dominant 20