Rabbit MDM2BP Polyclonal Antibody | anti-MDM2BP antibody

MDM2BP Polyclonal Antibody

Cat. Num. AAA3015485

• Gene Names: MTBP; MDM2BP
• Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep
• Applications: Immunohistochemistry
• Purity: affinity purified by Protein A
• Synonyms: MDM2BP; Polyclonal Antibody; MDM2BP Polyclonal Antibody; MDM 2 binding protein; MDM 2 BP; MDM2 (mouse double minute 2) binding protein 104kD; MDM2 (mouse double minute 2) binding protein; MDM2 binding protein; MDM2 BP; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein; Mouse double minute 2 homolog binding protein; MTBP_HUMAN; anti-MDM2BP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep
• Clonality: Polyclonal
• Specificity: MDM2BP Polyclonal Antibody detects endogenous levels of MDM2BP protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-MDM2BP antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:100-500
• Immunogen: KLH conjugated synthetic peptide derived from human MTBP/MDM2BP:821-904/904
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Paraformaldehyde-fixed, paraffin embedded (mouse ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MDM2BP) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C)

Immunohistochemistry (IHC)

(Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MDM2BP) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C)

Related Product Information for anti-MDM2BP antibody

This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation.

NCBI and Uniprot Product Information

• NCBI GI #: 21630257
• NCBI GeneID: 27085
• NCBI Accession #: NP_071328
• NCBI GenBank Nucleotide #: NM_022045.4
• UniProt Accession #: Q96DY7; Q9HA89; B4DUR5
• Molecular Weight: 104 kDa
• NCBI Official Full Name: mdm2-binding protein
• NCBI Official Synonym Full Names: MDM2 binding protein
• NCBI Official Symbol: MTBP
• NCBI Official Synonym Symbols: MDM2BP
• NCBI Protein Information: mdm2-binding protein; MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa
• UniProt Protein Name: Mdm2-binding protein
• UniProt Gene Name: MTBP
• UniProt Synonym Gene Names: hMTBP
• UniProt Entry Name: MTBP_HUMAN

NCBI Description

This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]

Uniprot Description

MTBP: Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Belongs to the MTBP family.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 8q24.12

Cellular Component: kinetochore; chromatin

Biological Process: negative regulation of cell proliferation; traversing start control point of mitotic cell cycle; negative regulation of mitosis; cell cycle arrest