Goat MCT2 Polyclonal Antibody | anti-MCT2 antibody

GOAT ANTI HUMAN MCT2

Cat. Num. AAA221698

• Gene Names: SLC16A7; MCT2
• Applications: Western Blot
• Synonyms: MCT2; Polyclonal Antibody; GOAT ANTI HUMAN MCT2; anti-MCT2 antibody

• Host: Goat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item recognises human monocarboxylate transporter 2 (MCT2). MCT2 is a transporter molecule involved in the transport of pyruvaste and lactate across cell membranes. ; ; Northern blot analysis reveals expression of a larger transcript in most normal tissues compared to that which predominates in many cell lines and this may be reflected in the two bands identified by this antibody, in Western blots.
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 0.5 mg/ml (varies by lot)
• Sequence Length: 478

• Applicable Applications for anti-MCT2 antibody: Western Blot (WB)
• Application Notes: Western Blot: This item detects bands of approximately 40 kDa and 60-70 kD in Raji cell lysates.; Western Blotting: Minimum Dilution: 1/200; Maximum Dilution: 1/500
• Perservative Stabilisers: 0.02% Sodium Azide; 0.5% Bovine Serum Albumin
• Immunogen: Synthetic peptide SNAQSVTSERETNI derived from C terminus of human MCT2.; Buffer Solution
• Antiserum Preparation: Antisera to human MCT2 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-MCT2 antibody

MBS221698 recognises human monocarboxylate transporter 2 (MCT2). MCT2 is a transporter molecule involved in the transport of pyruvaste and lactate across cell membranes. Northern blot analysis reveals expression of a larger transcript in most normal tissues compared to that which predominates in many cell lines and this may be reflected in the two bands identified by this antibody, in Western blots.

NCBI and Uniprot Product Information

• NCBI GI #: 397739033
• NCBI GeneID: 9194
• NCBI Accession #: NP_001257551.1
• NCBI GenBank Nucleotide #: NM_001270622.1
• UniProt Accession #: O60669; Q8NEM3; Q9UPB3
• Molecular Weight: 52,200 Da
• NCBI Official Full Name: monocarboxylate transporter 2
• NCBI Official Synonym Full Names: solute carrier family 16 (monocarboxylate transporter), member 7
• NCBI Official Symbol: SLC16A7
• NCBI Official Synonym Symbols: MCT2
• NCBI Protein Information: monocarboxylate transporter 2; solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
• UniProt Protein Name: Monocarboxylate transporter 2
• UniProt Gene Name: SLC16A7
• UniProt Synonym Gene Names: MCT2; MCT 2
• UniProt Entry Name: MOT2_HUMAN

NCBI Description

This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Description

SLC16A7: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: pyruvate secondary active transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; pyruvate transmembrane transporter activity

Biological Process: transmembrane transport