Rabbit MCT1/MCTS1 Polyclonal Antibody | anti-MCTS1 antibody

Anti-MCT1/MCTS1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8102052

• Gene Names: MCTS1; MCT1; MCT-1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: MCT1/MCTS1; Polyclonal Antibody; Anti-MCT1/MCTS1 Antibody; Rabbit Polyclonal; MCTS1/Malignant T cell amplified sequence 1 Antibody; Rabbit PAb; Antigen Affinity Purified; malignant T cell amplified sequence 1; Anti-MCT-1 Antibody; Anti-MCT1 Antibody; anti-MCTS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human MCT1/MCTS1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-MCTS1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human MCTS1/Malignant T cell amplified sequence 1
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human MCTS1/Malignant T cell amplified sequence 1, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining MCTS1 in human pancreas with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Immunohistochemistry (IHC)

(Immunochemical staining MCTS1 in mouse pancreas with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining MCTS1 in rat rectum with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-MCTS1 antibody

MCTS1 (MCTS1 Re-Initiation And Release Factor) is a Protein Coding gene. The encoded protein belongs to the MCTS1 family. Density-regulated reinitiation and release factor (DENR) and multiple copies in T-cell lymphoma-1 (MCTS1) are implicated in promoting translation reinitiation both in vitro in translation extracts and in vivo. The crystal structure of MCTS1 is bound to a fragment of DENR. Since DENR-MCTS1 can bind tRNA in the absence of the ribosome, this suggests the DENR-MCTS1 complex could recruit tRNA to the ribosome during reinitiation analogously to the eukaryotic initiation factor 2 (eIF2) complex in cap-dependent translation. MCTS1 is widely expressed in the lymph node, brain, and other tissues. Diseases associated with MCTS1 include Lymphoma.

NCBI and Uniprot Product Information

• NCBI GI #: 212276121
• NCBI GeneID: 28985
• NCBI Accession #: NP_001131026.1
• NCBI GenBank Nucleotide #: NM_001137554.1
• UniProt Accession #: Q9ULC4; Q502X6; B4DGY2
• Molecular Weight: 20,550 Da
• NCBI Official Full Name: malignant T-cell-amplified sequence 1 isoform 2
• NCBI Official Synonym Full Names: malignant T cell amplified sequence 1
• NCBI Official Symbol: MCTS1
• NCBI Official Synonym Symbols: MCT1; MCT-1
• NCBI Protein Information: malignant T-cell-amplified sequence 1; multiple copies T-cell malignancies
• UniProt Protein Name: Malignant T-cell-amplified sequence 1
• Protein Family: Malignant T-cell-amplified sequence
• UniProt Gene Name: MCTS1
• UniProt Synonym Gene Names: MCT1; MCT-1
• UniProt Entry Name: MCTS1_HUMAN

Uniprot Description

MCTS1: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Belongs to the MCTS1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytoplasm; plasma membrane

Molecular Function: translation initiation factor activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of growth; positive regulation of cell proliferation; ribosome disassembly; cell cycle; response to DNA damage stimulus; formation of translation preinitiation complex