Rabbit anti-Human MCT1 Polyclonal Antibody | anti-SLC16A1 antibody

MCT1, CT (Monocarboxylate Transporter 1, MCT 1, Solute Carrier Family 16 Member 1, SLC16A1)

Cat. Num. AAA628052

• Gene Names: SLC16A1; MCT; HHF7; MCT1; FLJ36745; MGC44475
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified; Purified by ammonium sulfate precipitation.
• Synonyms: MCT1; Polyclonal Antibody; CT (Monocarboxylate Transporter 1; MCT 1; Solute Carrier Family 16 Member 1; SLC16A1); Anti -MCT1; anti-SLC16A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SLC16A1 at ~53kD.
• Purity/Purification: Purified; Purified by ammonium sulfate precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-SLC16A1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:50-1:100
• Immunogen: Synthetic peptide coirresponding to aa437-467 from the C-terminal region of human SLC16A1, conjugated to KLH (P53985) (Gene ID 6566). Cellular Localization: Cell membrane; Multi-pass membrane protein
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of T47D cell line lysates (35ug/lane), using MBS628052 .SLC16A1(arrow) was detected using the purified Pab.)

Related Product Information for anti-SLC16A1 antibody

SLC16A1 is a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT.

Product Categories/Family for anti-SLC16A1 antibody

Antibodies; Abs to Monocarboxylate Transporter

NCBI and Uniprot Product Information

• NCBI GI #: 262073007
• NCBI GeneID: 6566
• NCBI Accession #: NP_001159968.1
• NCBI GenBank Nucleotide #: NM_001166496.1
• UniProt Accession #: P53985; Q5T8R6; Q9NSJ9; Q49A45; Q5T8R3; Q5T8R4; Q5T8R5
• Molecular Weight: 53,944 Da
• NCBI Official Full Name: monocarboxylate transporter 1
• NCBI Official Synonym Full Names: solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
• NCBI Official Symbol: SLC16A1
• NCBI Official Synonym Symbols: MCT; HHF7; MCT1; FLJ36745; MGC44475
• NCBI Protein Information: monocarboxylate transporter 1; MCT 1; OTTHUMP00000013960; OTTHUMP00000013961; solute carrier family 16 member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1
• UniProt Protein Name: Monocarboxylate transporter 1
• Protein Family: Monocarboxylate transporter
• UniProt Gene Name: SLC16A1
• UniProt Synonym Gene Names: MCT1
• UniProt Entry Name: MOT1_HUMAN

NCBI Description

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.

Uniprot Description

MCT1: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT); also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7); also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 1p12

Cellular Component: centrosome; mitochondrion; membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: mevalonate transmembrane transporter activity; protein homodimerization activity; monocarboxylic acid transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity

Biological Process: response to food; cellular metabolic process; monocarboxylic acid transport; centrosome organization and biogenesis; mevalonate transport; lipid metabolic process; glucose homeostasis; blood coagulation; pyruvate metabolic process; regulation of insulin secretion; transmembrane transport; leukocyte migration; behavioral response to nutrient

Disease: Erythrocyte Lactate Transporter Defect; Monocarboxylate Transporter 1 Deficiency; Hyperinsulinemic Hypoglycemia, Familial, 7