Rabbit anti-Human MCT1 Polyclonal Antibody | anti-MCT1 antibody

MCT1, CT (Monocarboxylate Transporter 1, MCT 1, Solute Carrier Family 16 Member 1, SLC16A1) (Biotin)

Cat. Num. AAA6488480

• Gene Names: SLC16A1; MCT; HHF7; MCT1; MCT1D
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A/G Affinity Chromatography
• Synonyms: MCT1; Polyclonal Antibody; CT (Monocarboxylate Transporter 1; MCT 1; Solute Carrier Family 16 Member 1; SLC16A1) (Biotin); anti-MCT1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SLC16A1 at ~53kD.
• Purity/Purification: Purified by Protein A/G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-MCT1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 430-460 in the C-terminal region of human MCT1.Cellular Localization: Cell membrane; Multi-pass membrane protein
• Conjugate: Biotin
• Positive Control: T47D cell lysates
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of T47D cell line lysates (35ug/lane), usingMBS628052.SLC16A1(arrow) was detected using the purified Pab.)

Related Product Information for anti-MCT1 antibody

SLC16A1 is a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT.

Product Categories/Family for anti-MCT1 antibody

Antibodies; Monocarboxylate Transporter

References

1. Pinheiro, C., Virchows Arch. 452(2), 139-146 (2008). 2. Otonkoski, T., Am. J. Hum. Genet. 81(3), 467-474 (2007). 3. Martin-Venegas, R., J. Nutr. 137(1), 49-54 (2007).

NCBI and Uniprot Product Information

• NCBI GI #: 115583685
• NCBI GeneID: 6566
• NCBI Accession #: NP_003042
• NCBI GenBank Nucleotide #: NM_003051
• UniProt Accession #: P53985
• Molecular Weight: 54kDa
• NCBI Official Full Name: monocarboxylate transporter 1
• NCBI Official Synonym Full Names: solute carrier family 16 member 1
• NCBI Official Symbol: SLC16A1
• NCBI Official Synonym Symbols: MCT; HHF7; MCT1; MCT1D
• NCBI Protein Information: monocarboxylate transporter 1
• UniProt Protein Name: Monocarboxylate transporter 1
• UniProt Gene Name: SLC16A1
• UniProt Synonym Gene Names: MCT1; MCT 1
• UniProt Entry Name: MOT1_HUMAN

NCBI Description

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]