Rabbit anti-Human MC4R Polyclonal Antibody | anti-MC4R antibody

MC4R Conjugated Antibody

Cat. Num. AAA9447418

• Reactivity: Human
• Applications: Most Applications
• Synonyms: MC4R; Polyclonal Antibody; MC4R Conjugated Antibody; MC4-R; MGC126851; MGC138197; anti-MC4R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total MC4R protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-MC4R antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to residues near the N terminal of human Melanocortin 4 receptor
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-MC4R antibody

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity

NCBI and Uniprot Product Information

• NCBI GI #: 119508433
• NCBI GeneID: 4160
• NCBI Accession #: NP_005903
• NCBI GenBank Nucleotide #: NM_005912.2
• UniProt Accession #: P32245; Q16317; Q3MIJ6; B2RAC3
• Molecular Weight: 36,943 Da
• NCBI Official Full Name: melanocortin receptor 4
• NCBI Official Synonym Full Names: melanocortin 4 receptor
• NCBI Official Symbol: MC4R
• NCBI Protein Information: melanocortin receptor 4; MC4-R
• UniProt Protein Name: Melanocortin receptor 4
• Protein Family: Melanocortin receptor
• UniProt Gene Name: MC4R
• UniProt Synonym Gene Names: MC4-R
• UniProt Entry Name: MC4R_HUMAN

NCBI Description

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]

Uniprot Description

MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: integral to membrane; plasma membrane; nucleus

Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; ubiquitin protein ligase binding; melanocyte stimulating hormone receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus

Disease: Obesity