Rabbit anti-Human WDR36 Polyclonal Antibody | anti-WDR36 antibody

WDR36 Antibody

Cat. Num. AAA9401982

• Gene Names: WDR36; GLC1G; UTP21; TAWDRP; TA-WDRP
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: WDR36; Polyclonal Antibody; WDR36 Antibody; GLC1G; UTP21; TAWDRP; TA-WDRP; anti-WDR36 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total WDR36 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 2.2 mg/ml (varies by lot)
• Sequence Length: 951

• Applicable Applications for anti-WDR36 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:200-1:1000; Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide of human WD repeat domain 36
• Target Name: WDR36
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 6%SDS-PAGE Lysate: 40ug K562 cellPrimary antibody: 1/200 dilution Secondary antibody dilution: 1/8000Exposure time: 1 minute)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/35.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/35.)

Related Product Information for anti-WDR36 antibody

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).

Product Categories/Family for anti-WDR36 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 21281677
• NCBI GeneID: 134430
• NCBI Accession #: NP_644810.1
• NCBI GenBank Nucleotide #: NM_139281.2
• UniProt Accession #: Q8NI36; Q68E02; Q8N1Q2; A2RUS4
• Molecular Weight: 105kd
• NCBI Official Full Name: WD repeat-containing protein 36
• NCBI Official Synonym Full Names: WD repeat domain 36
• NCBI Official Symbol: WDR36
• NCBI Official Synonym Symbols: GLC1G; UTP21; TAWDRP; TA-WDRP
• NCBI Protein Information: WD repeat-containing protein 36
• UniProt Protein Name: WD repeat-containing protein 36
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR36
• UniProt Synonym Gene Names: TA-WDRP
• UniProt Entry Name: WDR36_HUMAN

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]

Uniprot Description

WDR36: Involved in T-cell activation and highly co-regulated with IL2. Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 5q22.1

Cellular Component: small subunit processome; nucleolus

Biological Process: retinal homeostasis; visual perception; response to stimulus; regulation of axon extension; rRNA processing

Disease: Glaucoma 1, Open Angle, G