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Immunofluorescence (IF) (Immunofluorescence analysis of A549 cells, using MBTPS2 Antibody. The picture on the right is blocked with the synthesized peptide.)

Rabbit MBTPS2 Polyclonal Antibody | anti-MBTPS2 antibody

MBTPS2 Antibody

Gene Names
MBTPS2; S2P; IFAP; KFSD; KFSDX; OLMSX; BRESEK
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, ELISA
Purity
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Synonyms
MBTPS2; Polyclonal Antibody; MBTPS2 Antibody; Membrane-bound transcription factor site-2 protease; S2P endopeptidase; Site-2 protease; Sterol regulatory element-binding proteins intramembrane protease; anti-MBTPS2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
MBTPS2 Antibody detects endogenous levels of total MBTPS2 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (varies by lot)
Sequence Length
519
Applicable Applications for anti-MBTPS2 antibody
Immunofluorescence (IF), ELISA (EIA)
Application Notes
IF: 1:100~1:500
ELISA: 1:20000
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human MBTPS2.
Immunogen Range
301-350
Preparation and Storage
Stable at -20 degree C for at least 1 year.

Immunofluorescence (IF)

(Immunofluorescence analysis of A549 cells, using MBTPS2 Antibody. The picture on the right is blocked with the synthesized peptide.)

Immunofluorescence (IF) (Immunofluorescence analysis of A549 cells, using MBTPS2 Antibody. The picture on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
57 kDa
NCBI Official Full Name
membrane-bound transcription factor site-2 protease
NCBI Official Synonym Full Names
membrane bound transcription factor peptidase, site 2
NCBI Official Symbol
MBTPS2
NCBI Official Synonym Symbols
S2P; IFAP; KFSD; KFSDX; OLMSX; BRESEK
NCBI Protein Information
membrane-bound transcription factor site-2 protease
UniProt Protein Name
Membrane-bound transcription factor site-2 protease
UniProt Gene Name
MBTPS2
UniProt Synonym Gene Names
S2P; SREBPs intramembrane protease

NCBI Description

This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]

Uniprot Description

Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.

Research Articles on MBTPS2

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Product Notes

The MBTPS2 mbtps2 (Catalog #AAA9506506) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MBTPS2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MBTPS2 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), ELISA (EIA). IF: 1:100~1:500 ELISA: 1:20000. Researchers should empirically determine the suitability of the MBTPS2 mbtps2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MBTPS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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