Rabbit anti-Human Matriptase Polyclonal Antibody | anti-ST14 antibody

Matriptase (ST14, Suppressor Of Tumorigenicity 14 Protein, Membrane-type Serine Protease 1, Serine Protease 14, Serine Protease TADG-15, Tumor-associated Differentially-expressed Gene 15 Protein, SNC19, Epitin, Prostamin, TADG15, MT-SP1, MTSP1, PRSS14)

Cat. Num. AAA6007259

• Gene Names: ST14; HAI; MTSP1; SNC19; MT-SP1; PRSS14; TADG15; TMPRSS14
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Matriptase; Polyclonal Antibody; Matriptase (ST14; Suppressor Of Tumorigenicity 14 Protein; Membrane-type Serine Protease 1; Serine Protease 14; Serine Protease TADG-15; Tumor-associated Differentially-expressed Gene 15 Protein; SNC19; Epitin; Prostamin; TADG15; MT-SP1; MTSP1; PRSS14); Anti -Matriptase (ST14; anti-ST14 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human ST14.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-ST14 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1000; Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
• Immunogen: Synthetic peptide corresponding to aa840-854 of human ST14 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Kidney (formalin-fixed, paraffin-embedded) stained with MBS6007259 (10ug/ml) followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-ST14 antibody

Matriptase, also called MT-SP1, TADG-15 and ST14, is a member of the type II transmembrane serine protease family and is expressed on most human epithelia as an 80-90kD acell surface glycoprotein. Processing, activation and shedding of the C-terminal 26kD peptidase S1 domain is complex and requires coexpression with its inhibitor, HAI-1. Matriptase activity is critical to epidermal barrier formation. It is overexpressed in a variety carcinomas. Human and mouse matriptase share 86% aa identity within the peptidase S1 domain.

Product Categories/Family for anti-ST14 antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 6647302
• NCBI GeneID: 6768
• UniProt Accession #: Q9Y5Y6; Q9BS01; Q9H3S0; Q9HB36; Q9HCA3
• Molecular Weight: 94,770 Da
• NCBI Official Full Name: matriptase
• NCBI Official Synonym Full Names: suppression of tumorigenicity 14 (colon carcinoma)
• NCBI Official Symbol: ST14
• NCBI Official Synonym Symbols: HAI; MTSP1; SNC19; MT-SP1; PRSS14; TADG15; TMPRSS14
• NCBI Protein Information: suppressor of tumorigenicity 14 protein; prostamin; serine protease 14; serine protease TADG-15; membrane-type serine protease 1; tumor associated differentially expressed gene 15 protein; tumor-associated differentially-expressed gene 15 protein; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
• UniProt Protein Name: Suppressor of tumorigenicity 14 protein
• Protein Family: Suppressor of tumorigenicity 14 protein
• UniProt Gene Name: ST14
• UniProt Synonym Gene Names: PRSS14; SNC19; TADG15; MT-SP1
• UniProt Entry Name: ST14_HUMAN

NCBI Description

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]

Uniprot Description

ST14: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH). ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Belongs to the peptidase S1 family.

Protein type: Membrane protein, integral; EC 3.4.21.109; Protease

Chromosomal Location of Human Ortholog: 11q24-q25

Cellular Component: extrinsic to plasma membrane; extracellular space; basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: keratinocyte differentiation; proteolysis

Disease: Ichthyosis, Congenital, Autosomal Recessive 11