Rabbit anti-Human MATK Polyclonal Antibody | anti-MATK antibody

MATK (Megakaryocyte-associated Tyrosine Kinase, CHK, CTK, HYL, Lsk, HYLTK, HHYLTK) (MaxLight 550)

Cat. Num. AAA6447643

• Gene Names: MATK; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: MATK; Polyclonal Antibody; MATK (Megakaryocyte-associated Tyrosine Kinase; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK) (MaxLight 550); anti-MATK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MATK.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-MATK antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human MATK.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-MATK antibody

Antibodies; Tyrosine Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 21450842
• NCBI GeneID: 4145
• NCBI Accession #: NP_002369.2
• NCBI GenBank Nucleotide #: NM_002378.3
• UniProt Accession #: P42679; Q9NST8; B3KNZ9
• Molecular Weight: 56,469 Da
• NCBI Official Full Name: megakaryocyte-associated tyrosine-protein kinase isoform b
• NCBI Official Synonym Full Names: megakaryocyte-associated tyrosine kinase
• NCBI Official Symbol: MATK
• NCBI Official Synonym Symbols: CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
• NCBI Protein Information: megakaryocyte-associated tyrosine-protein kinase; protein kinase HYL; HYL tyrosine kinase; tyrosine kinase MATK; CSK homologous kinase; Csk-homologous kinase; tyrosylprotein kinase; hydroxyaryl-protein kinase; tyrosine-protein kinase CTK; Csk-type protein
• UniProt Protein Name: Megakaryocyte-associated tyrosine-protein kinase
• Protein Family: Maturase
• UniProt Gene Name: MATK
• UniProt Synonym Gene Names: CTK; HYL; CHK
• UniProt Entry Name: MATK_HUMAN

NCBI Description

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CTK: a non-receptor tyrosine kinase. Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. Expressed in cancerous but not normal breast tissue; interacts with activated ERBB2 receptor and is likely to inhibit proliferation.

Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.2; TK group; Csk family

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extrinsic to internal side of plasma membrane; cytosol

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: cell proliferation; cell migration; positive regulation of cell proliferation; morphogenesis of an epithelium; innate immune response; mesoderm development; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation