Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse brain using Mark4 Polyclonal Antibody at dilution of 1:200)
Rabbit anti-Mouse MARK4 Polyclonal Antibody | anti-MARK4 antibody
MARK4 Polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse brain using Mark4 Polyclonal Antibody at dilution of 1:200)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse brain using Mark4 Polyclonal Antibody at dilution of 1:200)
NCBI and Uniprot Product Information
Uniprot Description
Serine/threonine-protein kinase (). Phosphorylates the microtubule-associated protein MAPT/TAU (). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (). Required for the initiation of axoneme extension during cilium assembly (). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (). Reduces neuronal cell survival (). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation ().
Research Articles on MARK4
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Product Notes
The MARK4 mark4 (Catalog #AAA2554061) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MARK4 Polyclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MARK4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the MARK4 mark4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MARK4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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