Rabbit anti-Human, Rat LSM4 Polyclonal Antibody | anti-LSM4 antibody

LSM4 (U6 snRNA-associated Sm-like Protein 4, Glycine Rich Protein, GRP, YER112W) (Biotin)

Cat. Num. AAA6424969

• Gene Names: LSM4; GRP; YER112W
• Reactivity: Human, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: LSM4; Polyclonal Antibody; LSM4 (U6 snRNA-associated Sm-like Protein 4; Glycine Rich Protein; GRP; YER112W) (Biotin); anti-LSM4 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes LSM4. Species Crossreactivity: human, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-LSM4 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human LSM4.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of MCF-7 cell line, using LSM4 antibody.)

Product Categories/Family for anti-LSM4 antibody

Antibodies; Amino Acids

NCBI and Uniprot Product Information

• NCBI GI #: 6912486
• NCBI GeneID: 25804
• NCBI Accession #: NP_036453.1
• NCBI GenBank Nucleotide #: NM_012321.4
• UniProt Accession #: Q9Y4Z0
• Molecular Weight: 15,350 Da
• NCBI Official Full Name: U6 snRNA-associated Sm-like protein LSm4 isoform 1
• NCBI Official Synonym Full Names: LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
• NCBI Official Symbol: LSM4
• NCBI Official Synonym Symbols: GRP; YER112W
• NCBI Protein Information: U6 snRNA-associated Sm-like protein LSm4; glycine-rich protein
• UniProt Protein Name: U6 snRNA-associated Sm-like protein LSm4
• Protein Family: Sm-like protein
• UniProt Gene Name: LSM4
• UniProt Synonym Gene Names: GRP
• UniProt Entry Name: LSM4_HUMAN

NCBI Description

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

LSM4: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.

Protein type: RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; cytosol

Molecular Function: protein binding

Biological Process: RNA splicing; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay