Rabbit anti-Human, Mouse MARCKS Polyclonal Antibody | anti-MARCKS antibody

MARCKS Rabbit Polyclonal

Cat. Num. AAA7601240

• Gene Names: MARCKS; MACS; 80K-L; PKCSL; PRKCSL
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MARCKS; Polyclonal Antibody; MARCKS Rabbit Polyclonal; anti-MARCKS antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 332

• Applicable Applications for anti-MARCKS antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Myristoylated alanine-rich protein kinase C substrate
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7601240 (Marcks antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 153070260
• NCBI GeneID: 4082
• NCBI Accession #: NP_002347.5
• NCBI GenBank Nucleotide #: NM_002356.6
• Molecular Weight: 31,555 Da
• NCBI Official Full Name: myristoylated alanine-rich C-kinase substrate
• NCBI Official Synonym Full Names: myristoylated alanine rich protein kinase C substrate
• NCBI Official Symbol: MARCKS
• NCBI Official Synonym Symbols: MACS; 80K-L; PKCSL; PRKCSL
• NCBI Protein Information: myristoylated alanine-rich C-kinase substrate
• UniProt Protein Name: Myristoylated alanine-rich C-kinase substrate
• Protein Family: MARCKS-related protein
• UniProt Gene Name: MARCKS
• UniProt Synonym Gene Names: MACS; PRKCSL; MARCKS; 80K-L protein; PKCSL
• UniProt Entry Name: MARCS_HUMAN

NCBI Description

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

MARCKS: the most prominent cellular substrate of protein kinase C. Binds calmodulin, actin, and synapsin. A filamentous actin cross-linking protein. Critical for normal brain development. Phosphorylation by PKC displaces it from the plasma membrane, inhibiting F-actin cross-linking activity. Plays a role in growth cone adhesion: its nonphosphorylated form stabilizes integrin-mediated adhesions, and its phosphorylation-triggered release from adhesions causes localized growth cone detachment. Highly expressed in immature T and B lymphocytes: its expression is highest in CD4-8- T cells and B-cell blasts generated by antigen receptor signaling. Its expression and phosphorylation are closely linked to microglial activation processes involved in pathological conditions such as neuroinflammation and neurodegeneration.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 6q22.2

Cellular Component: actin cytoskeleton; cell cortex; centrosome; cytosol; dendritic spine; focal adhesion; germinal vesicle; growth cone; lysosome; microtubule; nerve terminal; outer dense fiber; plasma membrane

Molecular Function: actin filament binding; calmodulin binding; phosphatidylserine binding; protein kinase C binding

Biological Process: actin filament organization; brain development; cell-substrate adhesion; intracellular protein transport; phospholipase D activation; regulation of insulin secretion