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Rabbit anti-Human, Mouse MAP7 Polyclonal Antibody | anti-MAP7 antibody

MAP7 Antibody

Gene Names
MAP7; EMAP115; E-MAP-115
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
MAP7; Polyclonal Antibody; MAP7 Antibody; dJ325F22.2 (microtubule-associated protein 7 (EMAP115; E-MAP- 115)); E MAP 115; E-MAP-115; EMAP115; Ensconsin; Epithelial microtubule associated protein of 115 kDa; Epithelial microtubule-associated protein of 115 kDa; MAP 7; MAP-7; Map7; MAP7_HUMAN; Microtubule associated protein 7; Microtubule-associated protein 7; anti-MAP7 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
MAP7 Antibody detects endogenous levels of MAP7.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-MAP7 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human MAP7.
Conjugation
Unconjugated
Similarity
Belongs to the MAP7 family.
Post Translational Modifications
The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis.
Subunit Structure
Interacts with TRPV4.
Tissue Specificity
Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.
Function
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
Note
Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
749
NCBI Official Full Name
Ensconsin
NCBI Official Synonym Full Names
microtubule-associated protein 7
NCBI Official Symbol
MAP7
NCBI Official Synonym Symbols
EMAP115; E-MAP-115
NCBI Protein Information
ensconsin; MAP-7; epithelial microtubule-associated protein of 115 kDa; dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))
UniProt Protein Name
Ensconsin
UniProt Gene Name
MAP7
UniProt Synonym Gene Names
E-MAP-115; MAP-7
UniProt Entry Name
MAP7_HUMAN

NCBI Description

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Uniprot Description

MAP7: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Belongs to the MAP7 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Microtubule-binding

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: microtubule cytoskeleton; microtubule; microtubule associated complex; basolateral plasma membrane; perinuclear region of cytoplasm; cytoplasm

Molecular Function: structural molecule activity; receptor binding

Biological Process: establishment and/or maintenance of cell polarity; microtubule cytoskeleton organization and biogenesis; response to osmotic stress

Research Articles on MAP7

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Product Notes

The MAP7 map7 (Catalog #AAA9631085) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAP7 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MAP7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the MAP7 map7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAP7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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