Rabbit anti-Human MAP1S Polyclonal Antibody | anti-MAP1S antibody

MAP1S Antibody (Center)

Cat. Num. AAA9200733

• Gene Names: MAP1S; MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1
• Reactivity: Human
• Applications: Western Blot, ELISA, Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: MAP1S; Polyclonal Antibody; MAP1S Antibody (Center); Microtubule-associated protein 1S; MAP-1S; BPY2-interacting protein 1; Microtubule-associated protein 8; Variable charge Y chromosome 2-interacting protein 1; VCY2-interacting protein 1; VCY2IP-1; MAP1S heavy chain; MAP1S light chain; BPY2IP1; C19orf5; MAP8; VCY2IP1; anti-MAP1S antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This MAP1S antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human MAP1S.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 493-520
• Sequence Length: 1059

• Applicable Applications for anti-MAP1S antibody: Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(MAP1S Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MAP1S antibody detected the MAP1S protein (arrow).)

Immunohistochemistry (IHC)

(MAP1S Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MAP1S Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Flow Cytometry (FC/FACS)

(MAP1S Antibody (Center) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-MAP1S antibody

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule-organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).

References

Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Wong, E.Y., et al. Biol. Reprod. 70(3):775-784(2004)
Liu, L., et al. In Vitro Cell. Dev. Biol. Anim. 38(10):582-594(2002)
Liu, L., et al. Genomics 79(1):124-136(2002)

NCBI and Uniprot Product Information

• NCBI GI #: 50428935
• NCBI GeneID: 55201
• NCBI Accession #: NP_060644.4
• NCBI GenBank Nucleotide #: NM_018174.5
• UniProt Accession #: Q66K74; Q27QB1; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; B4DH53
• Molecular Weight: 112211
• NCBI Official Full Name: microtubule-associated protein 1S isoform 1
• NCBI Official Synonym Full Names: microtubule-associated protein 1S
• NCBI Official Symbol: MAP1S
• NCBI Official Synonym Symbols: MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1
• NCBI Protein Information: microtubule-associated protein 1S
• UniProt Protein Name: Microtubule-associated protein 1S
• Protein Family: Microtubule-associated protein
• UniProt Gene Name: MAP1S
• UniProt Synonym Gene Names: BPY2IP1; C19orf5; MAP8; VCY2IP1; MAP-1S; VCY2-interacting protein 1; VCY2IP-1
• UniProt Entry Name: MAP1S_HUMAN

Uniprot Description

BPY2-IP1: Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule-organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles. Belongs to the MAP1 family.

Protein type: Microtubule-binding; Apoptosis

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: microtubule; cell projection; cell soma; perinuclear region of cytoplasm; dendrite; cytoplasm; nucleolus; spindle; synapse; cell junction; nucleus; cytosol

Molecular Function: actin filament binding; tubulin binding; identical protein binding; protein binding; DNA binding; microtubule binding; deoxyribonuclease activity; beta-tubulin binding

Biological Process: nervous system development; brain development; DNA fragmentation during apoptosis; microtubule bundle formation; neurite morphogenesis; mitochondrion transport along microtubule