Rabbit anti-Human MAP Kinase Kinase 6 Polyclonal Antibody | anti-MAP2K6 antibody

MAP Kinase Kinase 6, phosphorylated (Ser207) (Dual Specificity Mitogen-activated Protein Kinase Kinase 6, MAP2K6, MAPKK 6, MAPKK6, MKK6, PRKMK6, MAPK/ERK Kinase 6, MEK 6, MEK6, Stress-activated Protein Kinase Kinase 3, SAPK Kinase 3, SAPKK3, SAPKK-3, SKK3

Cat. Num. AAA626386

• Gene Names: MAP2K6; MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: MAP Kinase Kinase 6; Polyclonal Antibody; phosphorylated (Ser207) (Dual Specificity Mitogen-activated Protein Kinase Kinase 6; MAP2K6; MAPKK 6; MAPKK6; MKK6; PRKMK6; MAPK/ERK Kinase 6; MEK 6; MEK6; Stress-activated Protein Kinase Kinase 3; SAPK Kinase 3; SAPKK3; SAPKK-3; SKK3; Anti -MAP Kinase Kinase 6; anti-MAP2K6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Detects endogenous levels of MKK6 only when phosphorylated at serine 207.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide and 50% glycerol.

• Applicable Applications for anti-MAP2K6 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1:500-1:1000; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthesized phosphopeptide derived from human MKK6 around the phosphorylation site of serine 207 (V-D-SP-V-A)
• Preparation and Storage: For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin embedded human breast carcinoma tissue using MBS626386.)

Western Blot (WB)

(Western Blot analysis of extracts from MDA-MB-435 cells treated or untreatedwith UV)

Product Categories/Family for anti-MAP2K6 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 1203818
• NCBI GeneID: 5608
• UniProt Accession #: P52564; Q6MZH7
• Molecular Weight: 37,492 Da
• NCBI Official Full Name: MAP kinase kinase 6
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase 6
• NCBI Official Symbol: MAP2K6
• NCBI Official Synonym Symbols: MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3
• NCBI Protein Information: dual specificity mitogen-activated protein kinase kinase 6; MEK 6; MAPKK 6; MAPK/ERK kinase 6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
• UniProt Protein Name: Dual specificity mitogen-activated protein kinase kinase 6
• Protein Family: Dual specificity mitogen-activated protein kinase kinase
• UniProt Gene Name: MAP2K6
• UniProt Synonym Gene Names: MEK6; MKK6; PRKMK6
• UniProt Entry Name: MP2K6_HUMAN

NCBI Description

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq]

Uniprot Description

MKK6: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported.

Protein type: Protein kinase, dual-specificity (non-receptor); Kinase, protein; EC 2.7.12.2; Protein kinase, STE; STE group; STE7 family

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: nucleoplasm; cytoskeleton; cytosol

Molecular Function: MAP kinase kinase activity; protein binding; protein-tyrosine kinase activity; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; DNA damage induced protein phosphorylation; positive regulation of apoptosis; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; pathogenesis; toll-like receptor 3 signaling pathway; signal transduction; toll-like receptor 10 signaling pathway; ovulation cycle process; toll-like receptor 5 signaling pathway; regulation of transcription, DNA-dependent; cell cycle arrest; toll-like receptor 4 signaling pathway; cardiac muscle contraction; response to drug; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; positive regulation of prostaglandin secretion; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; toll-like receptor 9 signaling pathway; positive regulation of nitric-oxide synthase biosynthetic process