Rabbit MAP-1 Polyclonal Antibody | anti-MOAP1 antibody
MAP-1 Polyclonal Antibody
This antibody recognizes human MAP-1 (Modulator of Apoptosis Protein), a novel Bax-associating protein. MAP-1 mediates caspase-dependent apoptosis in mammalian cells when overexpressed. MAP-1 homodimerizes and associates with the proapoptotic Bax and the prosurvival Bcl-2 and Bcl-xL of the Bcl-2 family.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq]
Uniprot Description
MOAP1: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Belongs to the PNMA family.
Chromosomal Location of Human Ortholog: 14q32
Cellular Component: mitochondrial outer membrane; mitochondrion; cytoplasm; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; protein insertion into mitochondrial membrane during induction of apoptosis; positive regulation of apoptosis
Research Articles on MOAP1
2. The association of RASSF1A and MOAP-1 with death receptors involves an ordered recruitment to receptor complexes to promote cell death and inhibit tumor formation.
3. Inhibition of ubiquitin-mediated degradation of MOAP1 by apoptotic stimuli promotes BAX function in mitochondria.
4. RASSF1A and MAP-1 are important components between death receptors and the apoptotic machenery.
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Product Notes
The MOAP1 moap1 (Catalog #AAA194297) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MAP-1 can be used in a range of immunoassay formats including, but not limited to, Immunoblot. Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 39 kD is detected. Researchers should empirically determine the suitability of the MOAP1 moap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAP-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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